| Identification | More | [Name]
2-Chloro-5-chloromethylthiophene | [CAS]
23784-96-5 | [Synonyms]
2-CHLORO-5-(CHLOROMETHYL)THIOPHENE
2-CHLORO-5-CHLOROMETHYLTHIOPHENE 98+%
5-Chloro-2-thenyl chloride | [Molecular Formula]
C5H4Cl2S | [MDL Number]
MFCD00009764 | [Molecular Weight]
167.06 | [MOL File]
23784-96-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to yellow liquid | [Uses]
2-Chloro-5-(chloromethyl)thiophene was used in the synthesis of 1-(1,1′-biphenyl-4-yl)-3-(5-chloro-thiophen-2-yl)-2-(1H-imidazol-1-yl)propane and 1-(5-chlorothiophen-2-yl)-2-(1H-imidazol-1-yl)-3-phenylpropane. | [Synthesis]
Under nitrogen protection, 5-chloro-2-thiophene methanol (500 mg, 3.37 mmol) was dissolved in tetrahydrofuran (10 mL) and cooled to 0 °C. Subsequently, CN (482 mg, 4.05 mmol) was added dropwise. After the dropwise addition, the reaction mixture was warmed up to 50 °C for 3 h, during which the reaction progress was monitored by TLC. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford 480 mg of 2-chloro-5-chloromethylthiophene in yellow liquid form (yield: 85.5%), which could be used directly in the subsequent reaction without further purification. | [References]
[1] Patent: CN107188865, 2017, A. Location in patent: Paragraph 0113; 0116; 0117 |
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| Company Name: |
Alfa Aesar
|
| Tel: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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