| Identification | More | [Name]
3-Bromo-5-fluoroanisole | [CAS]
29578-39-0 | [Synonyms]
1-BROMO-3-FLUORO-5-METHOXYBENZENE
3-BROMO-5-FLUOROANISOLE
5-BROMO-3-FLUOROANISOLE
3-FLUORO-5-BROMO ANISOLE,=98%
3-Bromo-5-fluoro-1-methoxybenzene | [Molecular Formula]
C7H6BrFO | [MDL Number]
MFCD01861129 | [Molecular Weight]
205.02 | [MOL File]
29578-39-0.mol |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless transparent liquid | [Uses]
3-fluoro-5-bromoanisole is an ether organic substance, which can be used as a pharmaceutical intermediate. | [Synthesis]
1. 1-Bromo-3,5-difluorobenzene (10 g, 0.052 mol) was dissolved in anhydrous DMF (300 mL) at 0-5 °C. 2. Sodium methanol (5.60 g, 0.1036 mol) was added to the above solution. 3. The reaction mixture was stirred at room temperature for 24 h. 4. Upon completion of the reaction, the reaction mixture was extracted three times with ethyl acetate. 5. The organic layers were combined, washed with brine and then dried with anhydrous Na2SO4. 6. The solvent was removed by evaporation to give 3-bromo-5-fluoroanisole (7.5 g, 71% yield). | [References]
[1] Patent: US2008/261941, 2008, A1. Location in patent: Page/Page column 43
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 2, p. 758 - 766
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 11, p. 1634 - 1647 |
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