| Identification | More | [Name]
4-(Trifluoromethyl)phenacyl bromide | [CAS]
383-53-9 | [Synonyms]
2-BROMO-1-[4-(TRIFLUOROMETHYL)PHENYL]-1-ETHANONE
2-BROMO-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-ONE
2-BROMO-4'-(TRIFLUOROMETHYL)ACETOPHENONE
4'-(TRIFLUOROMETHYL)PHENACYL BROMIDE
4-TRIFLUOROMETHYLPHENACYL BROMIDE
BUTTPARK 35\01-55
2-Bromo-1-[4-(trifluoromethyl)phenyl]ethan-1-one, tech
4-(Trifluoromethyl)phenacyl bromide 97%
4-(Trifluoromethyl)phenacylbromide97%
4-(TRIFLUOROMETHYL)PHENACYL BROMIDE: TECH.
2-Bromo-4'-(trifluoromethyl)acetophenon | [EINECS(EC#)]
609-544-9 | [Molecular Formula]
C9H6BrF3O | [MDL Number]
MFCD00126489 | [Molecular Weight]
267.04 | [MOL File]
383-53-9.mol |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36:Wear suitable protective clothing . | [RIDADR ]
1759 | [WGK Germany ]
3 | [Hazard Note ]
Corrosive | [HazardClass ]
CORROSIVE | [PackingGroup ]
III | [HS Code ]
29147000 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder or crystal | [Synthesis]
General procedure for the synthesis of 2-bromo-4'-(trifluoromethyl)acetophenone using 1-(bromoethynyl)-4-(trifluoromethyl)benzene as starting material: a mixed solution of haloalkynes (0.5 mmol), silver fluoride (5 mol%), and water (1 eq.) in trifluoroacetic acid (1 mL) was stirred for 6 hours at 40 °C. Upon completion of the reaction, the trifluoroacetic acid was recovered by distillation for reuse. The residue was purified by column chromatographic separation to afford the target product 2-bromo-4'-(trifluoromethyl)acetophenone. | [References]
[1] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1373 - 1375
[2] European Journal of Organic Chemistry, 2016, vol. 2016, # 1, p. 116 - 121
[3] Tetrahedron, 2016, vol. 72, # 27-28, p. 3818 - 3822
[4] Tetrahedron Letters, 2016, vol. 57, # 45, p. 4983 - 4986
[5] Chinese Journal of Chemistry, 2016, vol. 34, # 12, p. 1251 - 1254 |
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