| Identification | More | [Name]
2-Amino-3-chloropyridine | [CAS]
39620-04-7 | [Synonyms]
2-AMINO-3-CHLOROPYRIDINE
3-CHLORO-2-PYRIDINYLAMINE
3-CHLORO-PYRIDIN-2-YLAMINE
AURORA 15088
IFLAB-BB F3099-7175
OTAVA-BB BB7110951381
3-chloro-2-aminopyridine97%
3-CHLOROPYRIDIN-2-AMINE
2-Pyridinamine,3-chloro-(9CI)
3-Chloro-2-aminopyridine
3-CHLOROPYPRIDIN-2-AMINE
Pyridinamine, 3-chloro
2-Amino-3-chloro pyridine ,97%
3-Chloropyridin-2-amine ,98% | [Molecular Formula]
C5H5ClN2 | [MDL Number]
MFCD03541052 | [Molecular Weight]
128.56 | [MOL File]
39620-04-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
59-62℃ | [Boiling point ]
207.0±20.0 °C(Predicted) | [density ]
1.326±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
powder to crystal | [pka]
4.14±0.36(Predicted) | [color ]
White to Orange to Green | [Detection Methods]
HPLC | [InChI]
InChI=1S/C5H5ClN2/c6-4-2-1-3-8-5(4)7/h1-3H,(H2,7,8) | [InChIKey]
RZJPBQGRCNJYBU-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=CC=C1Cl | [CAS DataBase Reference]
39620-04-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Light green solid | [Synthesis Reference(s)]
Journal of Heterocyclic Chemistry, 24, p. 1313, 1987 DOI: 10.1002/jhet.5570240516 | [Synthesis]
The general procedure for the synthesis of 3-chloro-2-aminopyridine from 3-chloro-2-nitropyridine was as follows: 3-chloro-2-nitropyridine (1.00 g, 6.31 mmol) was dissolved in methanol (10 mL), and stannic(II) chloride (5.98 g, 31.54 mmol) and concentrated hydrochloric acid (2.63 mL, 31.54 mmol) were added sequentially. The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction solution was diluted with ethyl acetate and washed with 1N NaOH solution. Subsequently, the organic phase was washed with saturated NaHCO3 solution and dried with anhydrous Na2SO4. Finally, the organic phase was concentrated under reduced pressure to afford the target product 3-chloro-2-aminopyridine (510.0 mg, 63% yield). The product was characterized by 1H NMR (400 MHz, CD3CN) with chemical shifts of δ 6.80 (m, 1H), 7.60 (d, 1H), 8.12 (d, 1H). | [References]
[1] Patent: WO2006/44775, 2006, A2. Location in patent: Page/Page column 64
[2] Patent: US2009/22670, 2009, A1. Location in patent: Page/Page column 25 |
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