| Identification | More | [Name]
2-Fluoropyridine-6-carboxylic acid | [CAS]
402-69-7 | [Synonyms]
2-FLUORO-6-PYRIDINECARBOXYLIC ACID
2-FLUOROPYRIDINE-6-CARBOXYLIC ACID
6-FLUOROPICOLINIC ACID
6-FLUOROPYRIDINE-2-CARBOXYLIC ACID
6-Fluoro-2-pyridinecarboxylicacid
2-Fluoropyridine-6-carboxylic acid 98%
2-Fluoropyridine-6-carboxylicacid98%
2-Fluoroyridine-6-carboxylicacid
2-Fluoropyridine-6-carboxylic acid ,97%
2-Pyridinecarboxylic acid, 6-fluoro- | [Molecular Formula]
C6H4FNO2 | [MDL Number]
MFCD02181193 | [Molecular Weight]
141.1 | [MOL File]
402-69-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
139-143 °C (lit.) | [Boiling point ]
306.3±22.0 °C(Predicted) | [density ]
1.419±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Powder or Crystalline Powder | [pka]
3.30±0.10(Predicted) | [color ]
White to yellow to pale brown | [Detection Methods]
HPLC | [CAS DataBase Reference]
402-69-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
White to light yellow powder | [Synthesis]
General procedure for the synthesis of 6-fluoro-2-pyridinecarboxylic acid from 2-fluoro-6-methylpyridine: to a solution of 2-fluoro-6-methylpyridine (2.5 g, 22.5 mmol) in water (170 ml) was added potassium permanganate (KMnO?, 2 g, 12.65 mmol) in batches and the mixture was heated to reflux. Subsequently, potassium permanganate (KMnO?, 8 g, 50.63 mmol) was added in batches and heating to reflux was continued for 3 hours. After completion of the reaction, the mixture was cooled and the precipitate was removed by filtration. The filtrate was acidified with hydrochloric acid (HCl) solution and subsequently concentrated under reduced pressure. The residue was ground with hot ethanol (EtOH), the solid was collected by filtration and the filtrate was concentrated to dryness under reduced pressure. 6-Fluoro-2-pyridinecarboxylic acid was finally obtained as a white solid (1.7 g, 53% yield); melting point 137 °C. | [References]
[1] Patent: WO2004/13135, 2004, A1. Location in patent: Page 46-47
[2] Patent: WO2004/13138, 2004, A2. Location in patent: Page 22
[3] Journal of Fluorine Chemistry, 2011, vol. 132, # 8, p. 541 - 547
[4] Journal of the American Chemical Society, 1949, vol. 71, p. 4152 |
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