| Identification | More | [Name]
2-Thiopheneglyoxylic acid | [CAS]
4075-59-6 | [Synonyms]
2-OXO-2-(2-THIENYL)ACETIC ACID
2-THIENYLGLYOXYLIC ACID
2-THIOPHENEGLYOXYLIC ACID
ALPHA-OXO-2-THIOPHENEACETIC ACID
RARECHEM AL BO 2203
THIOPHENE-2-GLYOXYLIC ACID
alpha-oxothiophen-2-acetic acid
α-oxo-2-thiopheneacetic acid
2-thioylformic acid
α-oxo-2-thiophenacetic acid
2-THIOPHENEGLYOXYLIC ACID 95%
Oxo(thien-2-yl)acetic acid
(2-Thienyl)oxoacetic acid
2-(2-Thienyl)-2-oxoacetic acid
2-Oxo-2-thiophen-2-ylacetic acid
2-Thienylglyoxalic acid
a-Thienylglyoxalic acid
2-(2-Thienyl)glyoxylic acid
Oxo(2-thienyl)acetic acid
α-Oxothiophene-2-acetic acid | [EINECS(EC#)]
223-794-2 | [Molecular Formula]
C6H4O3S | [MDL Number]
MFCD00005441 | [Molecular Weight]
156.16 | [MOL File]
4075-59-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
88-91 °C (lit.) | [Boiling point ]
250.38°C (rough estimate) | [density ]
1.404 (estimate) | [refractive index ]
1.5151 (estimate) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
solid | [pka]
2.09±0.54(Predicted) | [Sensitive ]
Hygroscopic | [BRN ]
115791 | [CAS DataBase Reference]
4075-59-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
2-Thiopheneglyoxylic acid was used in the synthesis of europium complexes. | [Synthesis]
The general procedure for the synthesis of 2-thiophene glyoxalate from ethyl thiophene-2-glyoxalate was as follows: to a solution of ethyl thiophene-2-glyoxalate (4 mL, 27.17 mmol) in ethanol (60 mL) was added an aqueous 4N sodium hydroxide solution (10.2 mL, 40.76 mmol). The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction solution was acidified with 2N aqueous hydrochloric acid to pH 2. Subsequently, the solvent was removed by vacuum distillation to afford 2-thiophene glyoxalic acid as a yellow solid product (quantitative yield). The resulting residue was used directly in the subsequent reaction without further purification.LCMS analysis (Method 2): [MH-] = 155 with a retention time of 0.71 min. | [References]
[1] Patent: WO2016/193244, 2016, A1. Location in patent: Page/Page column 80
[2] Chemical Communications, 2014, vol. 50, # 34, p. 4489 - 4491
[3] Patent: WO2016/177849, 2016, A1. Location in patent: Page/Page column 60
[4] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4184 - 4190 |
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