| Identification | More | [Name]
METHYL 4-ACETAMIDO-2-METHOXYBENZOATE | [CAS]
4093-28-1 | [Synonyms]
4-ACETYLAMINO-2-HYDROXY-BENZOIC ACID METHYL ESTER
4-ACETYLAMINO-2-METHOXY-BENZOIC ACID METHYL ESTER
METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
METHYL 4-ACETAMIDO-2-METHOXYBENZOATE
METHYL 4-(ACETYLAMINO)-2-HYDROXYBENZENECARBOXYLATE
METHYL 4-(ACETYLAMINO)-2-HYDROXYBENZOATE
methyl 4-(acetylamino)salicylate
Methyl-2-metroxy-4-acetylaminobenzoate
2-Methoxy-4-acetylaminobenzoicacidmethylester
4-Acetamidosalicylic acid methyl ester
METHYL-2-METHOXY-4-ACETYLAMINOBENZOATE
4-ACETAMIDO-2-HYDROXY-BENZOIC ACID METHYL ESTER
Methyl 4-(acetylamino)-2-hydroxybenzoate, Methyl 4-acetamidosalicylate | [EINECS(EC#)]
223-838-0 | [Molecular Formula]
C11H13NO4 | [MDL Number]
MFCD00065258 | [Molecular Weight]
223.23 | [MOL File]
4093-28-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
146-147° | [Boiling point ]
405.1±35.0 °C(Predicted) | [density ]
1.317±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
9.29±0.10(Predicted) | [color ]
Light Orange to Light Brown | [InChI]
InChI=1S/C10H11NO4/c1-6(12)11-7-3-4-8(9(13)5-7)10(14)15-2/h3-5,13H,1-2H3,(H,11,12) | [InChIKey]
LCXHOHRQXZMSQN-UHFFFAOYSA-N | [SMILES]
C(OC)(=O)C1=CC=C(NC(C)=O)C=C1O | [CAS DataBase Reference]
4093-28-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Light Brown Solid | [Uses]
Methyl 4-Acetamido-2-hydroxybenzoate is a reagent used in the synthesis of Mosapride.
| [Synthesis]
Methyl 4-amino-2-hydroxybenzoate (50.7 g, 303.6 mmol) was dissolved in ethyl acetate (750 mL) with stirred water (250 mL) and sodium bicarbonate solution (34.9 g). The mixture was cooled to 0°C over 15 minutes, followed by slow dropwise addition of acetyl chloride (29.7 mL, 415.5 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 2 hours. After completion of the reaction, the organic and aqueous layers were separated, the organic layer was washed with brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the white solid product methyl 4-acetamido-2-hydroxybenzoate (63.5 g, 99% yield). The product was confirmed by NMR hydrogen spectrum (CDCl3): δ10.86 (broad single peak, 1H), 7.78 (double peak, J=8.6Hz, 1H), 7.23 (single peak, 1H), 7.16 (broad single peak, 1H), 7.10 (double peak, J=8.6Hz, 1H), 6.13 (broad single peak, 1H), 3.92 (single peak, 3H), 2.19 ( single peak, 3H); mass spectrum (m/z): 208 (MH)+. | [References]
[1] Patent: WO2013/42135, 2013, A1. Location in patent: Page/Page column 11
[2] Patent: US2014/187581, 2014, A1. Location in patent: Paragraph 0095-0097
[3] Organic Process Research and Development, 2010, vol. 14, # 1, p. 92 - 98
[4] Patent: US2016/251376, 2016, A1. Location in patent: Paragraph 0955; 0956; 0957
[5] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 22, p. 2657 - 2662 |
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