| Identification | Back Directory | [Name]
PEG7-Tos | [CAS]
42749-28-0 | [Synonyms]
PEG7-Tos
Tos-PEG6-OH
OH-PEG6-OTS
OH-PEG6-Tos
Hydroxy-peg7-ots
Tos-PEG6-alcohol
HO-(CH2CH2O)6-Tos
3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, 1-4-methylbenzenesulfonate
17-[(4-methylbenzenesulfonyl)oxy]-3,6,9,12,15-pentaoxaheptadecan-1-ol
toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester | [Molecular Formula]
C19H32O9S | [MDL Number]
MFCD20926395 | [MOL File]
42749-28-0.mol | [Molecular Weight]
436.52 |
| Chemical Properties | Back Directory | [Boiling point ]
555.5±50.0 °C(Predicted) | [density ]
1.196±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
PEG7-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Tos-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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