| Identification | Back Directory | [Name]
Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate) | [CAS]
77544-68-4 | [Synonyms]
PEG4-Tos
PEG3-Tos
77544-68-4
OH-PEG3-Tos
Tos-PEG3-OH
os-PEG3-alcohol
Hydroxy-PEG3-Tos
Tos-PEG4-alcohol
Tos-PEG3-alcohol
Triethylene glycol p-toluenesulfonate
2-(2-(2-Hydroxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate)
Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate) | [Molecular Formula]
C13H20O6S | [MDL Number]
MFCD22574797 | [MOL File]
77544-68-4.mol | [Molecular Weight]
304.36 |
| Chemical Properties | Back Directory | [Boiling point ]
460.0±35.0 °C(Predicted) | [density ]
1.234±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Ethanol: 100 mg/mL (328.56 mM); DMSO: 100 mg/mL (328.56 mM and warming) | [form ]
Solid-Liquid Mixture | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to light yellow | [Water Solubility ]
Water: 10 mg/mL (32.86 mM) |
| Hazard Information | Back Directory | [Description]
PEG3-Tos is a PEG linker containing a hydroxyl group and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports[1]. | [References]
[1] No?l M, et al. Solid Supports for the Synthesis of 3'-Aminooxy Deoxy- or Ribo-oligonucleotides and Their 3'-Conjugation by Oxime Ligation.J Org Chem. 2019 Nov 15;84(22):14854-14860. DOI:10.1021/acs.joc.9b00848 |
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