| Identification | Back Directory | [Name]
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA- | [CAS]
186020-66-6 | [Synonyms]
OH-PEG3-TBA
HO-PEG3-tBu
186020-66-6
HO-PEG3-COOtBu
OH-PEG3-CH2CH2COOtBu
HO-PEG3-CH2CH2COOtBu
HO-PEG3-t-Butyl ester
Hydroxy-PEG4-t-butyles
Hydroxy-PEG3-(CH2)2-Boc
12-HYDROXY-4 7 10-TRIOXA-
Hydroxy-PEG4-t-butylester
HO(CH2CH2O)3CH2CH2COOT-BU
tert-Butyl PEG3 propanoate
TERT-BUTYL 12-HYDROXY-4 7 10-TRIOXA-
tert-Butyl 3-(2-(2-(2-hydroxyethoxy)
12-Hydroxy-4,7,10-trioxadodecanoic Acid tert-Butyl Ester
tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate >=97.0% (GC)
3-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester
Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C13H26O6 | [MDL Number]
MFCD03791106 | [MOL File]
186020-66-6.mol | [Molecular Weight]
278.342 |
| Chemical Properties | Back Directory | [Boiling point ]
365.8±27.0 °C(Predicted) | [density ]
1.052 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.446
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Soluble in DMSO | [form ]
clear liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to Light yellow to Light orange | [BRN ]
7638988 | [CAS DataBase Reference]
186020-66-6 |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG3-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Biological Activity]
Tert-Butyl-12-hydroxy-4,7,10-trioxadodecanoate is an ADC linker for the synthesis of antibody drug conjugates (ADC), it is derived from patent WO2004008101A2 (compound 196). It can also be used as a PROTAC linker for PROTAC synthesis. . | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| Non-cleavable < span> | PEGs | Alkyl/ether | |
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