| Identification | More | [Name]
4,6-Dichloro-5-nitropyrimidine | [CAS]
4316-93-2 | [Synonyms]
4,6-DICHLORO-5-NITROPYRIMIDINE
5-NITRO-4,6-DICHLOROPYRIMIDINE
AKOS 91435
AKOS BBS-00003102
IFLAB-BB F1371-0158
TIMTEC-BB SBB010041
4,6-dichloro-5-nitropyridine
4,6-DICHLORO-5-NITROPYRIMIDINE, 97+%
4,6-Dichloro-5-Nitro-Pyrimidin
4,6-Dichloro-5-nitropyrimidine ,98% | [EINECS(EC#)]
224-340-6 | [Molecular Formula]
C4HCl2N3O2 | [MDL Number]
MFCD00006107 | [Molecular Weight]
193.98 | [MOL File]
4316-93-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Crystalline Solid | [Melting point ]
100-103 °C (lit.) | [Boiling point ]
325.8±37.0 °C(Predicted) | [density ]
1.737±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform, Ethyl Acetate, Methanol, Toluene | [form ]
Solid | [pka]
-7.48±0.26(Predicted) | [color ]
White to Off-White | [Detection Methods]
HPLC | [BRN ]
162029 | [InChI]
InChI=1S/C4HCl2N3O2/c5-3-2(9(10)11)4(6)8-1-7-3/h1H | [InChIKey]
HCTISZQLTGAYOX-UHFFFAOYSA-N | [SMILES]
C1=NC(Cl)=C([N+]([O-])=O)C(Cl)=N1 | [CAS DataBase Reference]
4316-93-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Pyrimidine, 4,6-dichloro-5-nitro-(4316-93-2) | [EPA Substance Registry System]
4316-93-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,T | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 3335 | [WGK Germany ]
3
| [RTECS ]
UV8258000
| [TSCA ]
Yes | [HS Code ]
29335990 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Nitric acid-->Phosphorus oxychloride-->Trifluoroacetic acid-->N,N-Diisopropylethylamine-->4,6-Dihydroxypyrimidine-->4,6-DIHYDROXY-5-NITROPYRIMIDINE-->5-Nitropyrimidine-4,6(1H,5H)-dione-->4-Pyrimidinamine, 6-chloro-N-methyl-5-nitro-N-phenyl--->6-Chloro-5-nitro-4(1H)-pyrimidinone-->N,N-Dimethylaniline | [Preparation Products]
Adenine-->6-Methylpurine-->4,6-Pyrimidinediamine,N4,N6-dimethyl-5-nitro--->N-benzyl-6-chloro-5-nitro-4-pyrimidinamine-->IFLAB-BB F2124-0140-->IFLAB-BB F2124-0129-->IFLAB-BB F2124-0130 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Crystalline Solid | [Uses]
4,6-Dichloro-5-nitropyrimidine (cas# 4316-93-2) is a compound useful in organic synthesis. | [Synthesis]
The general procedure for the synthesis of 4,6-dichloro-5-nitropyrimidine using 5-nitro-4,6-dihydroxypyrimidine as starting material was as follows: to a suspension of phosphoryl chloride (96 mL, 1056 mmol) containing 4,6-dihydroxy-5-nitropyrimidine (25 g, 160 mmol) was added dimethylaniline (32.6 mL, 246 mmol). The reaction mixture was heated in an oil bath at 125 °C and subsequently warmed to 130 °C and held for 1 hour. Upon completion of the reaction, excess trichlorophosphorus oxide was removed by evaporation. The residue was slowly poured onto ice (300 g) and the solid formed was subsequently collected by filtration. The filtrate was extracted with ether and the combined organic layers were washed sequentially with water and brine and dried with anhydrous sodium sulfate. After removal of the solvent by evaporation, the residue was purified by fast column chromatography in dichloromethane to afford the light brown solid product 4,6-dichloro-5-nitropyrimidine (21.5 g, 70% yield). The 1H NMR (DMSO-D6) data of the product were as follows: δ 8.3 (s, 1H, Ar). | [Purification Methods]
If too impure, then dissolve it in Et2O, wash it with H2O, dry it over MgSO4, evaporate it to dryness and recrystallise it from pet ether (b 85-105o) to give a light tan solid. It is soluble in ca 8 parts of MeOH [Boon et al. J Chem Soc 96 1951, Montgomery et al. in Synthetic Procedures in Nucleic Acid Chemistry Zorbach & Tipson eds, Wiley & Sons, NY, p76 1968]. [Beilstein 23 III/IV 899.] | [References]
[1] Journal of Labelled Compounds and Radiopharmaceuticals, 2008, vol. 51, # 1, p. 54 - 58
[2] Patent: EP1598354, 2005, A1. Location in patent: Page/Page column 90
[3] Pharmaceutical Chemistry Journal, 2000, vol. 34, # 3, p. 110 - 112
[4] Journal of Medicinal Chemistry, 2000, vol. 43, # 22, p. 4288 - 4312 |
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