| Identification | More | [Name]
3-Morpholinopropanol | [CAS]
4441-30-9 | [Synonyms]
3-(4-MORPHOLINE)PROPANOL
3-(4-morpholinyl)-1-propanol
3-MORPHOLIN-4-YL-PROPAN-1-OL
3-MORPHOLIN-4-YL-PROPAN-OL
3-MORPHOLINOPROPANOL
4-(3-HYDROXYPROPYL)MORPHOLINE
4-MORPHOLINEPROPANOL
AKOS BC-0903
gamma-morpholinopropanol
3-(4-Morpholinyl)-1-propanol, 3-Morpholinopropanol
3-Morpholino-1-propanol | [Molecular Formula]
C7H15NO2 | [MDL Number]
MFCD01713533 | [Molecular Weight]
145.2 | [MOL File]
4441-30-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
110-111.5 °C | [Boiling point ]
240-241 °C(lit.) | [density ]
1.049 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.4770(lit.)
| [Fp ]
185 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [form ]
clear liquid | [pka]
15.07±0.10(Predicted) | [color ]
Light yellow to Yellow to Orange | [CAS DataBase Reference]
4441-30-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
3267 | [WGK Germany ]
2
| [RTECS ]
QE9104700
| [HazardClass ]
8 | [PackingGroup ]
Ⅲ | [HS Code ]
2933998090 |
| Hazard Information | Back Directory | [Uses]
4-(3-Hydroxypropyl)morpholine may be used in the synthesis of macrocyclic urea compounds, which can act as potent Chk1 inhibitors. | [Synthesis]
To the reaction flask was added 913.5 g of toluene as solvent, followed by 174 g of morpholine and 556 g of 3-bromo-1-propanol. Under stirring conditions, 331.2 g of potassium carbonate was slowly added as a base. The reaction mixture was heated to 75-80 °C and the reaction was maintained at this temperature with stirring for 8 hours. Upon completion of the reaction, pressurized filtration was performed to remove solid impurities. Subsequently, the filtrate was concentrated to remove toluene and unreacted feedstocks, resulting in 278.4 g of a pale yellow oily liquid, the target product 3-(4-morpholinyl)-1-propanol. The molar yield of this step was 96% and the purity of the product was 98.5%. | [References]
[1] Patent: CN106045942, 2016, A. Location in patent: Paragraph 0023; 0020
[2] Patent: CN103382206, 2016, B. Location in patent: Paragraph 0235-0238
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 4, p. 871 - 887
[4] Patent: WO2004/108677, 2004, A1. Location in patent: Page 141
[5] Patent: US6265411, 2001, B1 |
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