| Identification | More | [Name]
2-Amino-5-bromobenzotrifluoride | [CAS]
445-02-3 | [Synonyms]
2-AMINO-5-BROMOBENZOTRIFLUORIDE
2-AMINO-5-BROMO(TRIFLUOROMETHYL)BENZENE
4-BROMO-2-(TRIFLUOROMETHYL)ANILINE
4-Bromo-alpha,alpha,alpha-trifluoro-o-toluidine
4-bromo-2-(trifluoromethyl)-benzenamin
o-Toluidine, 4-bromo-alpha,alpha,alpha-trifluoro-
2-Amino-5-bromobenzotrifluoride, 98% (4-Bromo-2-trifluoromethylaniline)
2-Amino-5-bromobenzotrifluoride 98%
2-Amino-5-bromobenzotrifluoride98%
4-bromo-2-(Trilfuoromethyl)aniline
4-BROMO-2-(TRIFLUOROMETHYL)ANILINE 97%
2-(Trifluoromethyl)-4-bromoaniline | [EINECS(EC#)]
207-150-8 | [Molecular Formula]
C7H5BrF3N | [MDL Number]
MFCD00064393 | [Molecular Weight]
240.02 | [MOL File]
445-02-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi,C | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S27:Take off immediately all contaminated clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
T | [HazardClass ]
6.1 | [HazardClass ]
IRRITANT | [HS Code ]
29214300 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear yellow liquid | [Uses]
4-Bromo-2-(trifluoromethyl)aniline has been used in the preparation of 2,5-dibromo-(trifluoromethyl)benzene and 5-bromo-2-iodo-(trifluoromethyl)benzene. | [Synthesis]
The general procedure for the synthesis of 2-amino-5-bromobenzotrifluoride from 1-(trifluoromethyl)-1,2-phenyliodo-3(1H)-one and 4-bromoaniline is as follows: in this embodiment, the same reaction and post-processing procedure as in Example 28 is used, wherein the aromatic amine is p-bromoaniline. The specific reaction conditions were as follows: 1-(trifluoromethyl)-1,2-phenyl iodo-3(1H)-one (0.5 mmol, 1.0 eq.), aromatic amine (1.5 mmol, 3.0 eq.), nickel hydroxide (10 μmol), and potassium carbonate (1.5 mmol, 3.0 eq.) were used as a base, and the reaction was carried out for 2 hours at 35°C in DMSO (2 mL). After the reaction was completed, post-treatment was performed according to the method of Example 1. | [References]
[1] Organic Letters, 2018, vol. 20, # 13, p. 3732 - 3735
[2] Patent: CN108503552, 2018, A. Location in patent: Paragraph 0232-0236
[3] Organic Letters, 2014, vol. 16, # 6, p. 1768 - 1771
[4] Patent: CN103553857, 2016, B. Location in patent: Paragraph 0019-0020 |
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