| Identification | More | [Name]
4-Fluoro-2-nitroanisole | [CAS]
445-83-0 | [Synonyms]
4-FLUORO-1-METHOXY-2-NITROBENZENE
4-FLUORO-2-NITROANISOLE
4-Fluoro-2-nitro-methoxybenzene
4-Fluoro-2-nitroanisole 98%
4-Fluoro-2-nitroanisole98%
1-Methoxy-2-nitro-4-fluorobenzene | [Molecular Formula]
C7H6FNO3 | [MDL Number]
MFCD00013375 | [Molecular Weight]
171.13 | [MOL File]
445-83-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
62-64 °C (lit.) | [Boiling point ]
272.4±20.0 °C(Predicted) | [density ]
1.321±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
soluble in Toluene | [form ]
powder to crystal | [color ]
Light orange to Yellow to Green | [CAS DataBase Reference]
445-83-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29093090 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow powder | [General Description]
4-Fluoro-2-nitroanisole is formed during the photolysis of the charge transfer complex of tetranitromethane and 4-fluoroanisole in dichloromethane at -20°C. | [Synthesis]
General procedure for the synthesis of 2-nitro-4-fluoroanisole from 2-nitro-4-fluorophenol and iodomethane: Acetonitrile (100 mL) solution of iodomethane (127.8 g, 0.9004 mol) was added slowly and dropwise to an acetonitrile (450 mL) solution containing 5-fluoro-2-nitrophenol (94.2 g, 0.600 mol) and potassium carbonate (207 g, 1.50 mol). mL) solution. The reaction mixture was heated to reflux for 15 hours. Upon completion of the reaction, the mixture was cooled to room temperature, filtered to remove insoluble solids, and the filter cake was washed twice with dichloromethane (100 mL). The filtrate and washings were combined and the solvent was evaporated to dryness by rotary evaporator to afford the crude product 2-nitro-4-fluoroanisole (96 g, 0.56 mol, 93% yield), which could be used in subsequent reactions without further purification. | [References]
[1] Patent: WO2005/26137, 2005, A2. Location in patent: Page/Page column 230-231
[2] Synthetic Communications, 1989, vol. 19, # 1, 2, p. 233 - 238 |
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