| Identification | More | [Name]
1-N-Boc-3-Cyanopyrrolidine | [CAS]
476493-40-0 | [Synonyms]
1-N-BOC-3-CYANO-PYRROLIDINE
3-CYANO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
TERT-BUTYL 3-CYANOPYRROLIDINE-1-CARBOXYLATE
1-Boc-3-cyanopyrrolidine
N-1-BOC-3-CYANOPYRROLIDINE | [Molecular Formula]
C10H16N2O2 | [MDL Number]
MFCD03001709 | [Molecular Weight]
196.25 | [MOL File]
476493-40-0.mol |
| Safety Data | Back Directory | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3439 | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
2933998090 |
| Hazard Information | Back Directory | [Uses]
1-N-Boc-3-cyanopyrrolidine is used to prepare aroyl-substituted pyrrolidines with monoamine reuptake inhibition activities. | [Synthesis]
A solution was prepared from tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate (2.65 g, 10 mmol) and sodium cyanide (2.5 g, 50 mmol) in N,N-dimethylformamide (100 mL). The reaction mixture was stirred at 100°C for 16 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into water and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure and the resulting residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate=5:1) to afford 1-N-Boc-3-cyanopyrrolidine (1.92 g, 98% yield). | [References]
[1] Patent: CN107474024, 2017, A. Location in patent: Paragraph 0385; 0392; 0393; 0394
[2] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 59; 60 |
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