| Identification | More | [Name]
3-CHLORO-4-METHOXYBENZALDEHYDE | [CAS]
4903-09-7 | [Synonyms]
3-CHLORO-4-METHOXYBENZALDEHYDE
3-CHLORO-4-METHOXYBENZENECARBALDEHYDE
3-CHLORO-P-ANISALDEHYDE
AKOS B029259
CHEMBRDG-BB 6945816
TIMTEC-BB SBB003854
3-chloroanisaldehyde
3-CHLORO-P-ANISALDEHYDE, 98+% GC | [EINECS(EC#)]
225-532-2 | [Molecular Formula]
C8H7ClO2 | [MDL Number]
MFCD00016601 | [Molecular Weight]
170.59 | [MOL File]
4903-09-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
56-60 °C (lit.) | [Boiling point ]
128 °C(Press: 5 Torr) | [density ]
1.244±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [color ]
White to Almost white | [Sensitive ]
Air Sensitive | [CAS DataBase Reference]
4903-09-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29130000 |
| Hazard Information | Back Directory | [Uses]
3-Chloro-4-methoxybenzaldehyde is mainly used in organic synthesis, as a drug intermediate and chemical reagent, and is widely used in pharmaceuticals, materials science and other fields. | [Synthesis]
Potassium carbonate (K2CO3, 7.6 g, 55.238 mmol) was added to a stirred solution of 3-chloro-4-hydroxybenzaldehyde (2.9 g, 18.412 mmol) in N,N-dimethylformamide (DMF, 30 mL). Iodomethane (CH3I, 7.80 g, 55.238 mmol) was added slowly and dropwise at room temperature under inert atmosphere. After the dropwise addition, the reaction mixture was heated to 80 °C and stirred continuously for 1 hour. Upon completion of the reaction, the reaction was quenched with deionized water (20 mL) and subsequently extracted with ethyl acetate (EtOAc, 2 x 50 mL). The organic phases were combined, washed sequentially with deionized water and saturated saline, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography to afford 3-chloro-4-methoxybenzaldehyde (2.78 g, 93% yield) as a yellow solid. | [References]
[1] Patent: US2003/176481, 2003, A1
[2] Patent: WO2009/158393, 2009, A1. Location in patent: Page/Page column 113-114
[3] Patent: US6313146, 2001, B1
[4] Patent: US6582351, 2003, B1 |
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