| Identification | More | [Name]
2-Nitro-N-hydroxyethyl aniline | [CAS]
4926-55-0 | [Synonyms]
2-[(2-NITROPHENYL)AMINO]ETHANOL
2-NITRO-N-(2-HYDROXYETHYL)ANILINE
2-NITRO-N-(HYDROXYETHYL)ANILINE
HC YELLOW 2
HC YELLOW NO 2
hc-yelow 2
JAROCOL YELLOW 2
N-(2-HYDROXYETHYL)-2-NITROANILINE
2-[(2-nitrophenyl)amino]-ethano
Ethanol,2-[(2-nitrophenyl)amino]-
2-(2-Nitroanilino)Ethanol
N-Hydroxyethyl-2-nitroaniline
2-(2-NitroPhenylamine)Ethanol(HcYellow2)
N-(2-HYDROXYETHYL)-ORTHO-NITROANILINE
N-(2-Nitrophenyl)-ethanolamine | [EINECS(EC#)]
225-555-8 | [Molecular Formula]
C8H10N2O3 | [MDL Number]
MFCD00239475 | [Molecular Weight]
182.18 | [MOL File]
4926-55-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Orange crystal powder | [Melting point ]
71-73°C | [Boiling point ]
376.6±22.0 °C(Predicted) | [density ]
1.352±0.06 g/cm3(Predicted) | [vapor pressure ]
0Pa at 20℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
14.60±0.10(Predicted) | [color ]
Dark Orange to Red | [Water Solubility ]
1.85g/L at 20℃ | [λmax]
441nm(NaOH aq.)(lit.) | [InChI]
InChI=1S/C8H10N2O3/c11-6-5-9-7-3-1-2-4-8(7)10(12)13/h1-4,9,11H,5-6H2 | [InChIKey]
LFOUYKNCQNVIGI-UHFFFAOYSA-N | [SMILES]
C(O)CNC1=CC=CC=C1[N+]([O-])=O | [LogP]
1.5 at 20℃ | [CAS DataBase Reference]
4926-55-0(CAS DataBase Reference) | [EPA Substance Registry System]
4926-55-0(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
Orange crystal powder | [Uses]
2-(2-Nitroanilino)ethanol is used in the preparation of (phenylamino)quinoxalinone derivatives which has been identified as a new class of glycogen phosphorylase inhibitors. | [Flammability and Explosibility]
Notclassified | [Synthesis]
In a 1L three-necked flask, 100 g of o-chloronitrobenzene, 450 g of hexane and 10 g of sodium fluoride were added sequentially and the temperature was raised to 80 °C. 60g of ethanolamine was slowly added dropwise, and the reaction temperature was maintained at 80°C for 20 hours. Sampling and analysis were carried out during the reaction, monitored by HPLC, and the reaction was terminated when the content of o-chloronitrobenzene was less than 3%. Upon completion of the reaction, decompression distillation was carried out to remove the solvent and the distillation temperature was controlled at 90 °C. Subsequently, methanol and water were added for crystallization, and after filtration, washing and drying, 103 g of red crystalline powder N-(2-nitrophenyl)ethanolamine was obtained, with a purity of 99.6% by HPLC. | [References]
[1] Heterocycles, 1999, vol. 51, # 11, p. 2561 - 2573
[2] Journal of the American Chemical Society, 1939, vol. 61, p. 1321,1323,1324
[3] Helvetica Chimica Acta, 1936, vol. 19, p. 1029,1030, 1033
[4] Chemische Berichte, 1947, vol. 80, p. 263,270
[5] Patent: US2434564, 1943, |
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