| Identification | More | [Name]
4-CHLORO-3-FLUOROANISOLE | [CAS]
501-29-1 | [Synonyms]
1-CHLORO-2-FLUORO-4-METHOXYBENZENE
4-CHLORO-3-FLUOROANISOLE
4-Chloro-3-fluoroanisole 98%
4-Chloro-3-fluoroanisole98%
3-Fluoro-4-chloroanisole | [Molecular Formula]
C7H6ClFO | [MDL Number]
MFCD00042570 | [Molecular Weight]
160.57 | [MOL File]
501-29-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
1993 | [Hazard Note ]
Irritant | [HS Code ]
2909309090 |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR COLOURLESS LIQUID | [Synthesis]
To a solution of acetone (10 mL) containing 4-chloro-3-fluorophenol (500 mg, 3.41 mmol) was added potassium carbonate (942.59 mg, 6.82 mmol) and iodomethane (1.94 g, 13.64 mmol). The reaction mixture was stirred at 60 °C for 16 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether:ethyl acetate = 20:1) to confirm the completion of the reaction. After completion of the reaction, the mixture was concentrated to remove the solvent. Water (20 mL) was added to the residue and extracted with ethyl acetate (20 mL x 3). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 4-chloro-3-fluoroanisole (470 mg, 2.93 mmol, 85.84% yield) as a colorless oil. | [References]
[1] Patent: CN105330698, 2016, A. Location in patent: Paragraph 0593; 0594; 0595; 0596
[2] Patent: WO2011/56652, 2011, A1. Location in patent: Page/Page column 118-119 |
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