| Identification | More | [Name]
9H-Carbazol-4-ol | [CAS]
52602-39-8 | [Synonyms]
4 HYDROXY 9(H)CARBAZOLE
4-HYDROXYCARBAZOLE
9H-CARBAZOL-4-OL
4-Carbazolol
SKF 106023
4-HYDROXYCARBAZOLE(CARVEDILOL INTERMEDIATE )
9H-CARBAZOLE-4-OL
p-HydroxycarBazole
9-H-CARBAZOL-4-OI
4-HYDROXYCARBAZOLE 98+% | [EINECS(EC#)]
258-034-9 | [Molecular Formula]
C12H9NO | [MDL Number]
MFCD02178385 | [Molecular Weight]
183.21 | [MOL File]
52602-39-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Light-Yellow Solid | [Melting point ]
169-173 °C (lit.) | [Boiling point ]
431.4±18.0 °C(Predicted) | [density ]
1.362±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightlty), Methanol (Slightly) | [form ]
Powder | [pka]
9.87±0.30(Predicted) | [color ]
Tan to cacao | [InChI]
InChI=1S/C12H9NO/c14-11-7-3-6-10-12(11)8-4-1-2-5-9(8)13-10/h1-7,13-14H | [InChIKey]
UEOHATPGKDSULR-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=CC=C2)C2=C1C=CC=C2O | [CAS DataBase Reference]
52602-39-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29339900 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Ethyl acetate-->Dichloromethane-->Hexane-->Palladium-->Diphenyl ether-->1,2,4-Trimethylbenzene-->1,2,3,9-Tetrahydro-4(H)-carbazol-4-one-->4H-Carbazol-4-one, 1,2,3,5,6,7,8,9-octahydro--->1,4-Dioxane-->Copper(II) chloride | [Preparation Products]
CARAZOLOL HCL-->Carvedilol Impurity 3-->4-Epoxypropanoxycarbazole-->N-2-Hydroxy-3-[[2-(Methoxyphenoxy)ethyl]aMine Carvedilol |
| Hazard Information | Back Directory | [Chemical Properties]
Light-Yellow Solid | [Uses]
4-Hydroxy Carbazole (cas# 52602-39-8) is a compound useful in organic synthesis. | [Synthesis]
Step 1: Preparation of 4-hydroxycarbazole; Nickel Nguyenay (35 g) was added to a reactor equipped with 1 L of water, followed by 1,2,3,9-tetrahydrocarbazol-4-one (50 g) and sodium hydroxide (15 g). The reaction mixture was heated to reflux and maintained for about 20 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was subsequently acidified to precipitate the solid product. The solid was collected by filtration and dried to give the crude 4-hydroxycarbazole. For further purification, the crude product can be dissolved in 10% sodium hydroxide solution, decolorized by activated carbon, and then the pH adjusted with dilute hydrochloric acid to precipitate the product. Finally, off-white to light gray 4-hydroxycarbazole crystals were obtained with a yield of about 50%. | [References]
[1] Journal of Organic Chemistry, 2006, vol. 71, # 22, p. 8384 - 8389
[2] Patent: WO2005/113502, 2005, A1. Location in patent: Page/Page column 14
[3] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 20, p. 2957 - 2961
[4] Journal of the Chemical Society, 1955, p. 3475
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2005, vol. 48, # 6, p. 407 - 419 |
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