| Identification | More | [Name]
2-Mercaptothiazole | [CAS]
5685-05-2 | [Synonyms]
2-Mercapto-1,3-thiazole
2-Thiazolethiol
4-Thiazoline-2-thione
Thiazoline-2-thione
2-Mercaptothiazole
Thiazole-2(3H)-thione | [EINECS(EC#)]
423-680-4 | [Molecular Formula]
C3H3NS2 | [Molecular Weight]
117.19 | [MOL File]
5685-05-2.mol |
| Hazard Information | Back Directory | [Uses]
2-Mercaptothiazole (Thiazoline-2-thione) is a thiazole compound that can be used as a basic structural unit in organic synthesis and is widely used in the pharmaceutical and chemical areas. | [Synthesis]
The general procedure for the synthesis of thiazole-2(3H)-thione from chloroacetaldehyde and ammonium dithiocarbamate was as follows: a 40% solution of chloroacetaldehyde (0.61 mol) was slowly added to 100 mL of water, keeping the reaction temperature below 5 °C. Subsequently, 67 g of ammonium dithiocarbamate (0.61 mol) was added in batches. After the addition was completed, the reaction mixture was gradually warmed up to room temperature and stirred continuously for 2 h to promote complete reaction. A white solid precipitated during the reaction and the product was collected by filtration. The resulting filter cake was washed sequentially with a small amount of ethanol and cold water to remove impurities. Finally, the product was dried to give 66.2 g of white solid thiazole-2(3H)-thione in 93% yield. | [References]
[1] Patent: TWI609015, 2017, B. Location in patent: Paragraph 0190 |
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