| Identification | More | [Name]
4-Bromo-2-fluorobenzaldehyde | [CAS]
57848-46-1 | [Synonyms]
2-FLUORO-4-BROMOBENZALDEHYDE
2-FLUORO-4-BROMOBENZALEDHYDE
4-BROMO-2-FLUOROBENZALDEHYDE
4-Bromo-2-Fluorobenzaldehyde 2-Fluoro-4-Bromobenzaldehyde
4-Bromo-2-fluorobenzaldehyde 98%
4-Bromo-2-fluorobenzaldehyde98%
Benzaldehyde, 4-bromo-2-fluoro- | [EINECS(EC#)]
611-583-1 | [Molecular Formula]
C7H4BrFO | [MDL Number]
MFCD00143261 | [Molecular Weight]
203.01 | [MOL File]
57848-46-1.mol |
| Chemical Properties | Back Directory | [Appearance]
lightyellowtobeigecrystal | [Melting point ]
58-62 °C (lit.) | [Boiling point ]
42°C 19mm | [density ]
1.6698 (rough estimate) | [refractive index ]
1.5700 (estimate) | [Fp ]
42°C/19mm | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [color ]
White to Orange to Green | [Water Solubility ]
INSOLUBLE | [Sensitive ]
Air Sensitive | [BRN ]
7700208 | [InChI]
InChI=1S/C7H4BrFO/c8-6-2-1-5(4-10)7(9)3-6/h1-4H | [InChIKey]
UPCARQPLANFGQJ-UHFFFAOYSA-N | [SMILES]
C(=O)C1=CC=C(Br)C=C1F | [CAS DataBase Reference]
57848-46-1(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Fluoro-4-bromobenzaldehyde(57848-46-1) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT, AIR SENSITIVE | [HS Code ]
29130000 |
| Hazard Information | Back Directory | [Chemical Properties]
lightyellowtobeigecrystal | [Uses]
4-Bromo-2-fluorobenzaldehyde is used in the synthesis of Nigeglanine hydrobromide. | [Synthesis]
General procedure for the synthesis of 4-bromo-2-fluorobenzaldehyde from 4-bromo-3-fluorobenzyl alcohol: To a solution of 4-bromo-3-fluorobenzyl alcohol (7.9 g, 38.5 mmol) in dichloromethane (160.0 mL) was added sodium acetate (940 mg, 11.5 mmol) and pyridinium chlorochromate (10.8 g, 50.0 mmol) sequentially. The reaction mixture was stirred at room temperature and protected from light for 2 hours. After completion of the reaction, the mixture was diluted with ethyl acetate (1.0 L) and filtered through a diatomaceous earth pad. The filtrate was washed sequentially with aqueous sodium bicarbonate (600 mL) and water (600 mL) and subsequently dried with anhydrous sodium sulfate. After evaporation of the solvent under reduced pressure, the resulting crude product was further purified by column chromatography to afford 4-bromo-2-fluorobenzaldehyde as a white solid (5.0 g, 63% yield). | [References]
[1] Patent: WO2011/21209, 2011, A1. Location in patent: Page/Page column 38; 39
[2] Patent: US2012/101099, 2012, A1. Location in patent: Page/Page column 13; 14 |
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