| Identification | More | [Name]
2-Chloro-3-amino-5-bromopyridine | [CAS]
588729-99-1 | [Synonyms]
3-AMINO-5-BROMO-2-CHLOROPYRIDINE
5-BROMO-2-CHLORO-3-PYRIDINAMINE
5-BROMO-2-CHLOROPYRIDIN-3-AMINE
5-BROMO-2-CHLORO-PYRIDIN-3-YLAMINE | [EINECS(EC#)]
675-552-4 | [Molecular Formula]
C5H4BrClN2 | [MDL Number]
MFCD02682092 | [Molecular Weight]
207.46 | [MOL File]
588729-99-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
129-132℃ | [Boiling point ]
296.8±35.0 °C(Predicted) | [density ]
1.834±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [pka]
0.03±0.10(Predicted) | [color ]
White to Orange to Green | [λmax]
314nm(EtOH)(lit.) | [InChI]
InChI=1S/C5H4BrClN2/c6-3-1-4(8)5(7)9-2-3/h1-2H,8H2 | [InChIKey]
ZSEZSALOLWCCGT-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=C(Br)C=C1N | [CAS DataBase Reference]
588729-99-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless solid | [Uses]
3-Amino-5-bromo-2-chloropyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [Synthesis]
Step 1: 2-Chloro-3-nitro-5-bromopyridine (2.38 g, 10 mmol) was dissolved in methanol (50 mL) and Raney nickel (0.5 g) was added. The reaction mixture was stirred overnight under hydrogen atmosphere. Upon completion of the reaction, the Raney nickel was removed by filtration and the filtrate was concentrated to afford 2-chloro-3-amino-5-bromopyridine (2.08 g, 100% yield), which could be used in subsequent reactions without further purification. Mass spectrum (ESI) m/z: 208.9 [M + 1]. | [References]
[1] Patent: EP2952510, 2015, A1. Location in patent: Paragraph 0146
[2] Patent: WO2008/157191, 2008, A2. Location in patent: Page/Page column 75
[3] Patent: WO2008/150827, 2008, A1. Location in patent: Page/Page column 69
[4] Journal of Heterocyclic Chemistry, 2003, vol. 40, # 2, p. 261 - 268
[5] Patent: US2012/238587, 2012, A1. Location in patent: Page/Page column 17 |
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