| Identification | More | [Name]
2-Amino-5-fluorobenzonitrile | [CAS]
61272-77-3 | [Synonyms]
2-AMINO-5-FLUOROBENZONITRILE
5-FLUOROANTHRANILONITRILE
5-FLUOROANTHRONILONITRILE
2-AMINO-5-FLUOROBENONITRILE | [Molecular Formula]
C7H5FN2 | [MDL Number]
MFCD02683869 | [Molecular Weight]
136.13 | [MOL File]
61272-77-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
92-96 °C (lit.) | [Boiling point ]
138 °C/15 mmHg (lit.) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
powder | [pka]
1.87±0.10(Predicted) | [color ]
Faint yellow to faint brown | [CAS DataBase Reference]
61272-77-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
3439 | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
2926907090 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Synthesis]
GENERAL METHODS: Azide-based compounds (1 mmol) were added to an aqueous solution (5 mL) containing freshly prepared Fe(0) nanoparticles (3 mmol) at room temperature and under argon atmosphere. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was extracted with ethyl acetate (3 × 10 mL), ensuring that all Fe-containing material was retained around the stir bar. Subsequently, the solvent in the organic phase was evaporated and the crude product was purified by short column chromatography. The final product was structurally confirmed by infrared spectroscopy (IR), proton nuclear magnetic resonance (1H NMR) and carbon nuclear magnetic resonance (13C NMR) data. | [References]
[1] Tetrahedron Letters, 2017, vol. 58, # 35, p. 3457 - 3460 |
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