| Identification | Back Directory | [Name]
Brofaromine | [CAS]
63638-91-5 | [Synonyms]
4-(7-bromo-5-methoxybenzofuran-2-yl)piperidine
4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine
Piperidine, 4-(7-bromo-5-methoxy-2-benzofuranyl)- | [Molecular Formula]
C14H16BrNO2 | [MOL File]
63638-91-5.mol | [Molecular Weight]
310.19 |
| Chemical Properties | Back Directory | [Boiling point ]
404.0±45.0 °C(Predicted) | [density ]
1.386±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (805.96 mM) | [form ]
Solid | [pka]
9.99±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2?μM for MAO-A. | [Biological Activity]
Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor, inhibits MAO-A with IC50 of 0.2 μM. | [in vitro]
In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC 50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC 50 range of Brofaromine is 0.01 μM to 0.1 μM. | [target]
| [storage]
Store at -20°C | [References]
[1] Boland A, et al. Pirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress-induced cell death through a mechanism unrelated to MAO-A inhibition. Br J Pharmacol. 2002 Feb;135(3):713-20. DOI:10.1038/sj.bjp.0704519 |
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