63638-91-5
63638-91-5 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10617 英文別名
4-(7-bromo-5-methoxybenzofuran-2-yl)piperidinePiperidine, 4-(7-bromo-5-methoxy-2-benzofuranyl)-
4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine
物理化學(xué)性質(zhì)
沸點(diǎn)404.0±45.0 °C(Predicted)
密度1.386±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 250 mg/mL (805.96 mM)
酸度系數(shù)(pKa)9.99±0.10(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
常見問題列表
生物活性
Brofaromine (CGP 11305A) 是一種單胺氧化酶 (MAO) 抑制劑，抑制 MAO-A，IC50 為 0.2 μM。靶點(diǎn)
IC50: 0.2 ?μM (MAO-A)
體外研究
In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC 50 is 0.19?μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10?μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC 50 range of Brofaromine is 0.01?μM to 0.1?μM.