| Identification | More | [Name]
ETHYL 2-METHYLTHIAZOLE-4-CARBOXYLATE | [CAS]
6436-59-5 | [Synonyms]
BUTTPARK 29\06-83
ETHYL 2-METHYL-1,3-THIAZOLE-4-CARBOXYLATE
ETHYL 2-METHYLTHIAZOL-4-CARBOXYLATE
ETHYL 2-METHYLTHIAZOLE-4-CARBOXYLATE
2-methylthiazole-4-carboxylic acid ethyl ester | [Molecular Formula]
C7H9NO2S | [MDL Number]
MFCD00156148 | [Molecular Weight]
171.22 | [MOL File]
6436-59-5.mol |
| Chemical Properties | Back Directory | [Appearance]
light yellowto brownpowde | [Melting point ]
54-58 °C | [Boiling point ]
242.1±13.0 °C(Predicted) | [density ]
1.198±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [pka]
1.10±0.10(Predicted) | [InChI]
InChI=1S/C7H9NO2S/c1-3-10-7(9)6-4-11-5(2)8-6/h4H,3H2,1-2H3 | [InChIKey]
QWWPUBQHZFHZSF-UHFFFAOYSA-N | [SMILES]
S1C=C(C(OCC)=O)N=C1C | [CAS DataBase Reference]
6436-59-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37:Wear suitable gloves . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29341000 |
| Hazard Information | Back Directory | [Chemical Properties]
light yellowto brownpowde | [Uses]
Ethyl 2-methylthiazole-4-carboxylate is a reactant used in the synthesis of 2,?4,?5-?trisubstituted thiazoles as antituberculosis agents effective against drug resistant tuberculosis. | [Synthesis]
Ethyl 2-methylthiazole-4-carboxylate was synthesized from ethyl 3-bromopyruvate and thioacetamide in ethanol (EtOH) at 250 W power, 25 kHz frequency, flow rate controlled at 2 mL/min, and reaction time of 1.5 hours. | [References]
[1] Journal of Organic Chemistry, 1997, vol. 62, # 12, p. 3804 - 3805
[2] Organic Letters, 2008, vol. 10, # 8, p. 1565 - 1568
[3] Journal of Organic Chemistry, 2001, vol. 66, # 19, p. 6410 - 6424
[4] Angewandte Chemie - International Edition, 2008, vol. 47, # 46, p. 8950 - 8953
[5] Patent: US2010/249404, 2010, A1. Location in patent: Page/Page column 11 |
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