| Identification | More | [Name]
2-Chloro-6-methyl-3-quinolinecarbaldehyde | [CAS]
73568-27-1 | [Synonyms]
2-CHLORO-6-METHYL-3-QUINOLINECARBALDEHYDE
2-CHLORO-6-METHYL-3-QUINOLINE CARBOXALDEHYDE
2-CHLORO-6-METHYLQUINOLINE-3-CARBALDEHYDE
2-CHLORO-6-METHYLQUINOLINE-3-CARBOXALDEHYDE
AKOS AU36-M570
AKOS BBS-00007323
ASISCHEM U98021
IFLAB-BB F0805-0003
TIMTEC-BB SBB000449
2-CHLORO-6-METHYLQUINOLINE-3-CARBOXALDE
2-CHLORO-6-METHYLQUINOLINE CARBOXALDEHYDE | [Molecular Formula]
C11H8ClNO | [MDL Number]
MFCD01912773 | [Molecular Weight]
205.64 | [MOL File]
73568-27-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
120-125 °C (lit.) | [Boiling point ]
350.8±37.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
powder to crystal | [pka]
-1.11±0.50(Predicted) | [color ]
Light orange to Yellow to Green | [CAS DataBase Reference]
73568-27-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
2933.49.7000 | [HazardClass ]
IRRITANT |
| Hazard Information | Back Directory | [Uses]
2-Chloro-6-methylquinoline-3-carboxaldehyde (cas# 73568-27-1) is a compound useful in organic synthesis. | [Synthesis]
Step 2: Phosphorus trichloride (237.2 g, 1.55 mol) was added dropwise to stirred N,N-dimethylformamide (40.4 g, 552.74 mmol) at 0 °C. N-p-tolylacetamide (33 g, 221.19 mmol) was subsequently added and the reaction mixture was kept stirring at reflux temperature overnight. Upon completion of the reaction, the reaction was quenched with 3000 mL of H2O/ice mixture. The pH of the mixture was adjusted to 9 by addition of Na2CO3. The reaction mixture was extracted with dichloromethane (3 x 3000 mL). The organic phases were combined and dried over anhydrous MgSO4 and subsequently concentrated under reduced pressure on a rotary evaporator. The crude product was purified by silica gel column chromatography with an eluent ratio of 1:10 ethyl acetate:hexane to give 15.3 g (34% yield) of 2-chloro-6-methylquinoline-3-carboxaldehyde as a yellow solid.LCMS detection showed a molecular ion peak of 206 (M + H)+. | [References]
[1] Synlett, 2001, # 2, p. 251 - 253
[2] Patent: CN104774221, 2017, B. Location in patent: Paragraph 0062
[3] Patent: CN104725431, 2017, B. Location in patent: Paragraph 0050
[4] Synthetic Communications, 2002, vol. 32, # 9, p. 1351 - 1356
[5] Journal of the Brazilian Chemical Society, 2014, vol. 25, # 2, p. 365 - 371 |
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