Identification | More | [Name]
N-Ethyl-3-carbazolecarboxaldehyde | [CAS]
7570-45-8 | [Synonyms]
3-FORMYL-N-ETHYLCARBAZOLE 9-ETHYL-3-CARBAZOLECARBOXALDEHYDE 9-ETHYL-9H-CARBAZOLE-3-CARBALDEHYDE 9-ETHYL-CARBAZOLE-3-CARBALDEHYDE AKOS B000241 AKOS BBS-00003258 N-ETHYL-3-CARBAZOLECARBOXALDEHYDE N-ETHYL CARBAZOLE-3-ALDEHYDE N-ETHYLCARBAZOLE-3-CARBALDEHYDE N-ETHYLCARBAZOLE-3-CARBOXALDEHYDE TIMTEC-BB SBB000622 9H-Carbazole-3-carboxaldehyde,9-ethyl- N-ethyl-3-formylcarbazole N-Ethylcarbazole-3-Carbaldehydealde 9-Ethyl-carbazole-3-aldehyde N-Ethyl-3-carbazolecarboxaldehyde, tech., 94% 9-ETHYLCARBAZOL-3-CARBALDEHYDE 9-Ethyl-9H-carbazole-3-carboxaldehyde N-Ethyl-3-carbazolecarboxaldehyde, 94%, tech. 9-ETHYLCARBAZOLE-3-CARBOXALDEHYDE | [EINECS(EC#)]
231-471-2 | [Molecular Formula]
C15H13NO | [MDL Number]
MFCD00004963 | [Molecular Weight]
223.27 | [MOL File]
7570-45-8.mol |
Chemical Properties | Back Directory | [Appearance]
yellow to ochre crystalline powder or granules | [Melting point ]
85-87 °C (lit.) | [Boiling point ]
255 °C / 15mmHg | [density ]
1.0707 (rough estimate) | [refractive index ]
1.5500 (estimate) | [storage temp. ]
Refrigerator (+4°C) | [solubility ]
soluble in Benzene,Toluene | [form ]
Crystalline Powder or Granules | [color ]
Yellow to ochre | [CAS DataBase Reference]
7570-45-8(CAS DataBase Reference) |
Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed. R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29339900 |
Hazard Information | Back Directory | [Chemical Properties]
yellow to ochre crystalline powder or granules | [Uses]
9-Ethyl-3-carbazolecarboxaldehyde was used in the synthesis of poly(vinyl acetal)s (PVAcs). | [Synthesis]
Phosphorus oxychloride (POCl3, 1.4 mL, 10.2 mmol) was slowly added dropwise to stirring N,N-dimethylformamide (DMF, 3.2 mL, 40.8 mmol) under ice bath conditions for a controlled period of 10 minutes. The resulting slightly reddish solution was continued to be stirred for 1 h at room temperature. Subsequently, 9-ethyl-9H-carbazole (1.0 g, 5.1 mmol) was added over 10 minutes and the reaction mixture was placed in a microwave reactor at 100 °C for 1 hour. Upon completion of the reaction, the reaction mixture was cooled to room temperature and then carefully poured into crushed ice to quench the reaction. After the mixture was warmed to room temperature, it was extracted with ethyl acetate (EtOAc). The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with different ratios of heptane/ethyl acetate (EtOAc) as eluent to afford N-ethylcarbazole-3-carbaldehyde as a white solid (1.054 g, 93% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and 13C NMR (101 MHz, CDCl3). | [References]
[1] European Journal of Medicinal Chemistry, 2018, vol. 159, p. 74 - 89 [2] Synthetic Communications, 2004, vol. 34, # 12, p. 2127 - 2133 [3] Chemistry Letters, 2008, vol. 37, # 6, p. 570 - 571 [4] Patent: WO2013/106460, 2013, A2. Location in patent: Paragraph 0198 [5] Journal of Molecular Structure, 2005, vol. 734, # 1-3, p. 35 - 44 |
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