| Identification | More | [Name]
5-BROMO-2-METHOXYBENZYL ALCOHOL | [CAS]
80866-82-6 | [Synonyms]
4-BROMO-2-(HYDROXYMETHYL)ANISOLE
5-BROMO-2-METHOXYBENZYL ALCOHOL
(5-BROMO-2-METHOXY-PHENYL)-METHANOL
5-BROMO-O-ANISYL ALCOHOL
RARECHEM AL BD 0053
5-Bromo-2-methoxybenzyl alcohol 98% | [EINECS(EC#)]
279-586-7 | [Molecular Formula]
C8H9BrO2 | [MDL Number]
MFCD00004630 | [Molecular Weight]
217.06 | [MOL File]
80866-82-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
68-71 °C (lit.) | [Boiling point ]
192.5°C (rough estimate) | [density ]
1.4816 (rough estimate) | [refractive index ]
1.4930 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
powder to crystal | [color ]
White to Light yellow | [CAS DataBase Reference]
80866-82-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29094990 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
5-Bromo-2-methoxybenzyl alcohol has been used in the synthesis of 5-bromo-2-methoxyphenylacetic acid. | [Synthesis]
GENERAL METHODS: Lithium bromide monohydrate (0.2 mmol) and iodobenzene diacetate (0.2 mmol) were added to a solution of 2-methoxybenzenemethanol (0.2 mmol) in trifluoroethanol (1 mL) and the reaction was carried out at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous sodium sulfite solution. The mixture was extracted with dichloromethane and the combined organic layers were washed with saturated brine and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to afford the target product 5-bromo-2-methoxybenzyl alcohol. | [References]
[1] Synlett, 2018, vol. 29, # 17, p. 2275 - 2278
[2] Tetrahedron Letters, 2000, vol. 41, # 46, p. 8881 - 8885
[3] Synthetic Communications, 2007, vol. 37, # 9, p. 1571 - 1577 |
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