| Identification | More | [Name]
2-Amino-4-bromopyridine | [CAS]
84249-14-9 | [Synonyms]
2-AMINO-4-BROMOPYRIDINE
4-BROMOPYRIDIN-2-AMINE
4-BROMO-PYRIDIN-2-YLAMINE
AKOS BBS-00001381
AURORA 23224
OTAVA-BB BB7110952492
4-Bromo-2-aminopyridine
4-Bromo-2-amine-pyridin | [EINECS(EC#)]
640-931-5 | [Molecular Formula]
C5H5BrN2 | [MDL Number]
MFCD01646115 | [Molecular Weight]
173.01 | [MOL File]
84249-14-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White to Beige Solid | [Melting point ]
142-146 °C | [Boiling point ]
268.2±20.0 °C(Predicted) | [density ]
1.710±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
5.72±0.11(Predicted) | [color ]
Off-White to Beige | [InChI]
InChI=1S/C5H5BrN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8) | [InChIKey]
BAQKUNMKVAPWGU-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=CC(Br)=C1 | [CAS DataBase Reference]
84249-14-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Beige Solid | [Uses]
2-Amino-4-bromopyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [Synthesis]
General procedure for the synthesis of 2-amino-4-bromopyridine from 2-Boc amine-4-bromopyridine: 2-Boc amine-4-bromopyridine (200 mg, 0.73 mmol) was suspended in water (1 mL) and hydrobromic acid (1 mL, 48 wt% aqueous solution) was added. The reaction mixture was stirred at room temperature for 16 h before being poured into aqueous sodium bicarbonate (25 mL) and extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, dried over magnesium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (pure ethyl acetate as eluent) to give 2-amino-4-bromopyridine. Yield: 73 mg (58%). LC/MS retention time: 0.69 min. m/z by mass spectrometry (electrospray positive ion mode): 175, 173 [M+H]+. | [References]
[1] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 301
[2] Patent: WO2007/89669, 2007, A2. Location in patent: Page/Page column 212-213
[3] Patent: WO2008/57469, 2008, A1. Location in patent: Page/Page column 301
[4] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 301
[5] Australian Journal of Chemistry, 1982, vol. 35, # 10, p. 2025 - 2034 |
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