| Identification | More | [Name]
2-Bromo-6-fluoroanisole | [CAS]
845829-94-9 | [Synonyms]
1-BROMO-3-FLUORO-2-METHOXY-BENZENE
2-BROMO-6-FLUOROANISOLE | [EINECS(EC#)]
679-553-0 | [Molecular Formula]
C7H6BrFO | [MDL Number]
MFCD04974125 | [Molecular Weight]
205.02 | [MOL File]
845829-94-9.mol |
| Chemical Properties | Back Directory | [Boiling point ]
208.6±20.0 °C(Predicted) | [density ]
1.531±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
liquid | [color ]
colorless | [InChI]
InChI=1S/C7H6BrFO/c1-10-7-5(8)3-2-4-6(7)9/h2-4H,1H3 | [InChIKey]
RLSQPLJXDTXSCL-UHFFFAOYSA-N | [SMILES]
C1(Br)=CC=CC(F)=C1OC | [CAS DataBase Reference]
845829-94-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to pale yellow liquid | [Uses]
2-Bromo-6-fluoroanisole is a reactant in the preparation of quinazolines as a c-jun N-terminal kinase (JNK) inhibitor with good brain penetration. | [Synthesis]
GENERAL METHOD: 2-bromo-6-fluorophenol (0.1 mol) was dissolved in DMF (100 mL) and K2CO3 (0.1 mol) and iodomethane (0.1 mol) were added sequentially. The reaction mixture was stirred at room temperature for 24 hours. After the reaction was completed, water (400 mL) was added to dilute and the mixture was extracted with hexane. The organic phase was separated, washed with water, dried over anhydrous sodium sulfate, filtered through a short column of silica gel and the filtrate was concentrated under reduced pressure to give 2-bromo-6-fluoroanisole. | [References]
[1] European Journal of Medicinal Chemistry, 2015, vol. 89, p. 524 - 539 |
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