| Identification | More | [Name]
1-Boc-3-hydroxypiperidine | [CAS]
85275-45-2 | [Synonyms]
1-BOC-3-HYDROXYPIPERIDINE
1-boc-3-piperidinol
1-N-BOC-3-HYDROXY-PIPERIDINE
1-TERT-BUTOXYCARBONYL-3-HYDROXY PIPERIDINE
3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
BOC-3-HYDROXYPIPERIDINE
BOC-(R,S)-3-HYDROXYPIPERIDINE
N-BOC-3-HYDROXYPIPERIDINE
N-BOC-3-PIPERIDINOL
N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE
RARECHEM EM WB 0260
(R,S)-BOC-3-HYDROXY-PIPERIDINE
TERT-BUTYL 3-HYDROXY-1-PIPERIDINE
tert-Butyl 3-hydroxy-1-piperidinecarboxylate
TERT-BUTYL 3-HYDROXYPIPERIDINE-1-CARBOXYLATE
1-Boc-3-piperidinol~1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
1-BOC-3-HYDROXYPIPERIDINE/1-TERT-BUTOXYCARBONYL-3-HYDROXY PIPERIDINE
3-Hydroxypiperidine, N-BOC protected
1-Boc-3-piperidinol, tert-Butyl 3-hydroxy-1-piperidinecarboxylate | [EINECS(EC#)]
628-428-9 | [Molecular Formula]
C10H19NO3 | [MDL Number]
MFCD02093938 | [Molecular Weight]
201.26 | [MOL File]
85275-45-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
65-67°C | [Boiling point ]
292.3±33.0 °C(Predicted) | [density ]
1.107±0.06 g/cm3(Predicted) | [storage temp. ]
Store at-15°C | [form ]
powder to crystal | [pka]
14.74±0.20(Predicted) | [color ]
White to Almost white | [BRN ]
4180859 | [InChI]
InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3 | [InChIKey]
UIJXHKXIOCDSEB-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCCC(O)C1 | [CAS DataBase Reference]
85275-45-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
It is a pharmaceutical intermediate. | [Synthesis]
1) At room temperature, 3-hydroxypiperidine (5.00 g) was dissolved in methanol (50 mL), to which a methanol (50 mL) solution of triethylamine (15.2 mL) and di-tert-butyl dicarbonate (11.9 g) were sequentially added. The reaction mixture was stirred for 15 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate-chloroform) to afford tert-butyl 3-hydroxypiperidine-1-carboxylate as a white solid (9.86 g, 99% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3) and EI-MS: 1H-NMR δ: 1.36-1.55 (2H, m), 1.45 (9H, s), 1.71-1.78 (1H, m), 1.88 (1H, m), 3.02-3.13 (2H, m), 3.52 (1H, m), 3.72-3.76 (2H, m); EI-MS m/z: 201 (M+). | [References]
[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 11, p. 3159 - 3171
[2] Patent: EP1762568, 2007, A1. Location in patent: Page/Page column 49-50
[3] Patent: EP1785418, 2007, A1. Location in patent: Page/Page column 47
[4] Patent: EP1107965, 2004, B1. Location in patent: Page 13
[5] Tetrahedron, 2011, vol. 67, # 7, p. 1485 - 1500 |
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