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ChemicalBook--->CAS DataBase List--->95975-55-6

95975-55-6

95975-55-6 Structure

95975-55-6 Structure
IdentificationMore
[Name]

(Z)-Guggulsterone
[CAS]

95975-55-6
[Synonyms]

4,17(20)-(CIS)-PREGNADIEN-3,16-DIONE
CIS-4,17(20)-PREGNADIENE-3,16-DIONE
CIS GUGGULSTERONE
GUGGULESTERONE Z
GUGGULSTERONE
GUGGULSTERONE Z
GUGGULSTERONE (Z FORM)
GUGULSTERONE
PREGNA-4,17(20)-DIENE-3,16-DIONE
(Z)-GUGGULSTERONE
(8S,9R,10R,13S,14S,17E)-17-(1-methoxyethylidene)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
pregna-4,17-diene-3,16-dione
GUGGULISTERONES 95%
(17Z)-Pregna-4,17(20)-diene-3,16-dione
(Z)-Guggulsterone
[EINECS(EC#)]

1308068-626-2
[Molecular Formula]

C21H28O2
[MDL Number]

MFCD01310757
[Molecular Weight]

312.45
[MOL File]

95975-55-6.mol
Chemical PropertiesBack Directory
[Boiling point ]

463.3±45.0 °C(Predicted)
[density ]

1.10±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: 5 mg/mL
[form ]

powder
[color ]

light yellow
[CAS DataBase Reference]

95975-55-6(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R37:Irritating to the respiratory system.
[Safety Statements ]

S36:Wear suitable protective clothing .
[WGK Germany ]

3
[HS Code ]

29147000
Hazard InformationBack Directory
[Uses]

Guggulsterone is a broad spectrum steroid receptor ligand. Gum resin of Commiphora mukul marketed as an antihyperlipidemic drug.
[Definition]

ChEBI: Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen.
[Biological Activity]

Broad spectrum steroid receptor ligand; binds with high affinity to mineralocorticoid receptors (K i = 39 nM) and lower affinity to progesterone, androgen and glucocorticoid receptors (K i values are 201, 240 and 224 nM respectively). Functions primarily as an antagonist of these receptors, with the exception of the progesterone receptor where it displays partial agonist effects. Also exerts hypolipidemic activity, likely via antagonism of the receptor for bile acids (farnesoid X receptor; FXR).
[in vivo]

Guggulsterone (orally; 100 mg/kg once per day for 8 days) significantly improved the survival rates of wild-type mice with TNBS-induced colitis[2].

Animal Model:Wild-type mice with TNBS-induced colitis[2]
Dosage:100 mg/kg
Administration:Orally; once per day; for 8 days
Result:Improved the survival rates of wild-type mice with TNBS-induced colitis.
[IC 50]

JNK; Caspase
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