101469-92-5

基本信息
(S)-1-叔丁氧羰基-3-羥基吡咯烷
(S)-1-N-BOC-3-吡咯烷醇
S-N-Boc-3-羥基吡咯烷
(S)-N-叔丁氧羰基-3-羥基吡咯烷
(S)-1-N-BOC-3-羥基吡咯烷
(S)-(+)-1-BOC-3-羥基吡咯烷, 99%, E
(3S)-(+)-N-BOC-3-HYDROXYPYRROLIDINE
BOC-(S)-3-HYDROXYPYRROLIDINE
N-BOC-(S)-3-HYDROXYPYRROLIDINE
N-T-BOC-(S)-3-HYDROXYPYRROLIDINE
N-(TERT-BUTOXYCARBONYL)-(S)-(+)-3-PYRROLIDINOL
(S)-(+)-1-BOC-3-HYDROXYPYRROLIDINE
(S)-1-BOC-3-HYDROXYPYRROLIDINE
(S)-1-BOC-3-PYRROLIDINOL
(S)-1-N-BOC-3-HYDROXYPYRROLIDINE
(S)-1-N-(T-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE
(S)-1-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE
(S)-3-HYDROXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(S)-(+)-BOC-3-PYRROLIDINOL
(S)-N-BOC-3-HYDROXYPYRROLIDINE HYDROCHLORIDE
(S)-N-BOC-3-PYRROLIDINOL
(S)-(+)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE
(S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPYRROLIDINE
(S)-TERT-BUTYL 3-HYDROXYPYRROLIDINE-1-CARBOXYLATE
(3S)-1-Boc-3-pyrrolidinol~(3S)-1-tert-Butoxycarbonyl-3-hydroxypyrrolidine
物理化學性質(zhì)
安全數(shù)據(jù)
制備方法

24424-99-5

40499-83-0

83220-73-9
以二碳酸二叔丁酯和3-羥基吡咯烷為原料合成1-叔丁氧基羰基-3-羥基-吡咯烷的一般步驟如下:首先,將(R)-3-吡咯烷醇(539mg,6.19mmol)轉(zhuǎn)化為化合物16b,得到無色油狀物(1.3g,收率100%)。該產(chǎn)物的光譜數(shù)據(jù)與預期結(jié)構(gòu)一致,并與文獻報道相符(參見Kucznierz, R.等人,J. Med. Chem. 1998, 41, 4983-4994)。隨后,化合物16b經(jīng)過反應轉(zhuǎn)化為化合物16c,同樣為無色油狀物。接著,通過兩步反應從化合物16c制備化合物16e,仍為無色油狀物。最后,化合物16e經(jīng)過進一步反應得到目標產(chǎn)物化合物16,呈現(xiàn)為黃色油狀物。
參考文獻:
[1] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 969 - 973
[2] Patent: WO2015/9731, 2015, A2. Location in patent: Paragraph 00106
[3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4983 - 4994
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 17, p. 5812 - 5832
[5] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 86
知名試劑公司產(chǎn)品信息
(S)-(+)-1-Boc-3-hydroxypyrrolidine, 99%, ee 99%(101469-92-5)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2025/05/22 | 39758 | (S)-(+)-1-Boc-3-羥基吡咯烷, ee 99% (S)-(+)-N-BOC-3-pyrrolidinol, 98+%, Thermo Scientific Chemicals | 101469-92-5 | 5g | 2794元 |
2025/05/22 | B3055 | (S)-1-(叔丁氧羰基)-3-吡咯烷醇 (S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol | 101469-92-5 | 1G | 70元 |
2025/05/22 | B3055 | (S)-1-(叔丁氧羰基)-3-吡咯烷醇 (S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol | 101469-92-5 | 5G | 265元 |