124401-38-3
124401-38-3 結(jié)構(gòu)式
基本信息
4-N-甲基-3-酮基-N-苯基戊酰胺
4-Methyl-3-oxopentanoic acid anilide
4-methyl-3-oxopentanoic acid phenylamide
4-METHYL-3-OXO-PENTANOIC PHENYLAMIDE
N-PHENYL-ISOBUTYLOYLACETAMIDE
N-PHENYL ISOBUTYRYLACETAMIDE
Isobutyrylacetanilide
N-PhNeyl-isobutyloyl Acetamide
物理化學(xué)性質(zhì)
制備方法
42558-54-3
62-53-3
124401-38-3
向1000 mL干燥的三口燒瓶中依次加入60 g（0.416 mol）異丁酰乙酸甲酯、120 g（1.288 mol）苯胺和6 g 4-二甲基氨基吡啶（DMAP）。開啟攪拌，緩慢升溫至內(nèi)溫100℃，保持此溫度反應(yīng)16小時。反應(yīng)過程中，通過分餾裝置收集生成的甲醇。反應(yīng)結(jié)束后，將體系降溫至70℃，減壓蒸餾回收未反應(yīng)的苯胺，共回收74.7 g苯胺，回收率為92%。剩余反應(yīng)液濃縮至約100 g后，加入1 kg水，冷卻至30℃并攪拌結(jié)晶5小時以上。過濾，用水洗滌濾餅3次，干燥后得到白色固體產(chǎn)物82.3 g。經(jīng)HPLC分析，產(chǎn)物純度為99.8%，收率為96.4%。
參考文獻(xiàn)：
[1] Patent: CN106397241, 2017, A. Location in patent: Paragraph 0014; 0015; 0016; 0017; 0018; 0019; 0020; 0021
[2] Patent: WO2012/143933, 2012, A1. Location in patent: Page/Page column 21-22
[3] Organic and Biomolecular Chemistry, 2016, vol. 14, # 7, p. 2291 - 2296
[4] Synthetic Communications, 2015, vol. 45, # 24, p. 2832 - 2840
[5] Journal of Heterocyclic Chemistry, 2007, vol. 44, # 4, p. 923 - 926
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | XW1244013833 | 4-甲基-3-酮基-N-苯基戊酰胺 4-methyl-3-oxo-n-phenylpentanamide;n-phenylisobutyloylacetamide;4-methyl-3-oxopentanoic acid anilide;4-methyl-3-oxopentanoic acid phenylamide | 124401-38-3 | 25G | 1031元 |
| 2025/05/22 | XW1244013832 | 4-甲基-3-酮基-N-苯基戊酰胺 4-methyl-3-oxo-n-phenylpentanamide;n-phenylisobutyloylacetamide;4-methyl-3-oxopentanoic acid anilide;4-methyl-3-oxopentanoic acid phenylamide | 124401-38-3 | 5G | 317元 |
| 2025/05/22 | XW1244013831 | 4-甲基-3-酮基-N-苯基戊酰胺 4-methyl-3-oxo-n-phenylpentanamide;n-phenylisobutyloylacetamide;4-methyl-3-oxopentanoic acid anilide;4-methyl-3-oxopentanoic acid phenylamide | 124401-38-3 | 1G | 104元 |