13362-26-0

基本信息
AKOS 90517
BUTTPARK 23\07-65
ETHYL 2-AMINONICOTINATE
RARECHEM AL BI 1234
Ethyl 2-aminopyridine-3-carboxylate
2-Amino-3-(ethoxycarbonyl)pyridine
2-Amino-3-carbethoxypyridine
2-Amino-3-pyridinecarboxylic Acid Ethyl Ester
Ethyl 2-aminonicotinate ,97%
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法

5345-47-1

64-17-5

13362-26-0
以2-氨基煙酸(1)(5g,36mmol)和乙醇(100mL)為原料,向其中加入濃硫酸(10mL)。將反應(yīng)混合物加熱回流16小時(shí),隨后冷卻至室溫。通過LC-MS分析確認(rèn)反應(yīng)完成。在真空條件下除去揮發(fā)物,加入水,用1N NaOH溶液將粗產(chǎn)物堿化至pH 8.0。將產(chǎn)物用乙酸乙酯萃取兩次,合并有機(jī)相,用硫酸鎂干燥后濃縮,得到2-氨基煙酸乙酯(2)(6.0g,100%產(chǎn)率),為白色結(jié)晶固體。HPLC-MS分析結(jié)果:保留時(shí)間t R = 0.41分鐘(UV 254nm);質(zhì)量計(jì)算值C8H10N2O2 166.1,實(shí)測(cè)值LCMS m/z 167.1(M + H)。
參考文獻(xiàn):
[1] Patent: WO2008/82490, 2008, A2. Location in patent: Page/Page column 70
[2] Patent: TWI525093, 2016, B. Location in patent: Page/Page column 101;
[3] Patent: WO2007/67416, 2007, A2. Location in patent: Page/Page column 64; 134
[4] Patent: WO2007/86080, 2007, A2. Location in patent: Page/Page column 37
[5] Heterocycles, 1993, vol. 36, # 11, p. 2513 - 2522