139756-02-8
139756-02-8 結(jié)構(gòu)式
基本信息
4-氨基-1-甲基-3-正丙基-1H(氫)-吡唑-5-羧酰胺
4-氨基-1-甲基-3-正丙基-1H-吡唑-5-羧酰胺
西地那非中間體
4-AMINO-1-METHYL-3-N-PROPYL-1H-PYRAZOLE-5-CARBOXAMIDE
4-AMINO-1-METHYL-3-N-PROPYL-5-PYRAZOLECARBOXAMIDE
4-AMINO-1-METHYL-3-N-PROPYL PYRAZOLE-5-CARBOXAMIDE
4-AMINO-1-METHYL-3-N-PROPYL PYRAZOLO-5-CARBOXAMIDE
4-AMINO-1-METHYL-3-N-PROPYPRZOLE-5-CARBOXAMIDE
4-AMINO-1-METHYL-3-PROPYL-1H-PYRAZOLE-5-CARBOXAMIDE
4-amino-1-methyl-3-propyl-5-pyrazolecarboxamide
4-AMINO-1-METHYL-3-PROPYL PYRAZOLE-5-CARBOXAMIDE
4-Amino-2-methyl-5-propyl-2H-pyrazole-3-carboxamide
4-AMINO-2-METHYL-5-PROPYL-2H-PYRAZOLE-3-CARBOXYLIC ACID AMIDE
VIAGRA INTERMEDIATE
1H-Pyrazole-5-carboxamide,4-amino-1-methyl-3-n-propyl
4-AMINO-1-METHYL-3-N-PROPYL-5-PYRAZOLECA
1H-Pyrazole-5-carboxamide,4-am
4-Amino-1-methyl-3-propyl-5-pyrazolecarboxam
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
139756-01-7
139756-02-8
步驟7 4-氨基-1-甲基-3-正丙基-1H-吡唑-5-甲酰胺的合成：將1-甲基-4-硝基-3-丙基-1H-吡唑-5-甲酰胺（14.7g，69.3mmol）懸浮于乙酸乙酯（130mL）中，加入10％鈀/碳催化劑（3.3g）。在50℃和4atm氫氣壓力下，將反應(yīng)混合物攪拌過夜。反應(yīng)完成后，冷卻至室溫，過濾除去催化劑，并用乙酸乙酯洗滌催化劑。合并的濾液用無水硫酸鎂干燥，過濾后減壓濃縮，得到白色固體4-氨基-1-甲基-3-正丙基-1H-吡唑-5-甲酰胺（13.8g，收率98％）。產(chǎn)物經(jīng)1H NMR（300MHz，CDCl3）確認(rèn)：δ4.12（s，3H），2.84（s，2H），2.55（t，2H，J = 7.2Hz），1.71-1.61（m，2H），0.99（t，3H，J = 7.2Hz）；LC-MS顯示m/z = 183（MH）+。
參考文獻(xiàn)：
[1] Patent: US2008/194529, 2008, A1. Location in patent: Page/Page column 57
[2] Patent: WO2014/131855, 2014, A1. Location in patent: Page/Page column 81
[3] Patent: WO2016/20307, 2016, A1. Location in patent: Page/Page column 51
[4] Patent: CN103044330, 2018, B. Location in patent: Paragraph 0025; 0031-0032; 0034-0035
[5] Patent: WO2015/114647, 2015, A1. Location in patent: Page/Page column 47; 48