142643-29-6
142643-29-6 結(jié)構(gòu)式
基本信息
3-叔丁氧羰基氨基哌啶
3-叔丁氧羰基氨甲基哌啶
3-BOC-氨基哌啶
3-BOC-氨基甲基-哌啶
3-AMINOPIPERIDINE, 3-BOC PROTECTED
(+/-)-3-(BOC-AMINOMETHYL)PIPERIDINE
3-BOC-AMINOMETHYL PIPERIDINE
3-BOC-AMINOPIPERIDINE
3-N-BOC-AMINOMETHYL PIPERIDINE
(+/-)-3-N-BOC-AMINO-PIPERIDINE
3-N-BOC-AMINO PIPERIDINE
3-(TERT-BUTOXYCARBONYLAMINO)PIPERIDINE
CARBAMIC ACID, 3-PIPERIDINYL-, 1,1-DIMETHYLETHYL ESTER
PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
(R)-PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
(R,S)-(BOC-3-AMINOMETHYL)-PIPERIDINE
(S)-PIPERIDIN-3-YLMETHYL-CARBAMIC ACID TERT-BUTYL ESTER
TERT-BUTYL N-(3-PIPERIDYLMETHYL)CARBAMATE
TERT-BUTYL PIPERIDIN-3-YLCARBAMATE
TERT-BUTYL (PIPERIDIN-3-YLMETHYL) CARBAMATE
3-Aminopiperidine, 3-BOC protected 97%
3-BOC-3-AMINOPIPERIDINE
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
220031-61-8
142643-29-6
向（1-芐基哌啶-3-基）甲基氨基甲酸叔丁酯（2.05 g，6.74 mmol，1.0當(dāng)量）的甲醇（40 mL）溶液中加入10% Pd(OH)2/C（0.21 g，10 wt%）。在氬氣保護(hù)下，向反應(yīng)體系中加入環(huán)己烯（6.80 mL，67.40 mmol，10.0當(dāng)量）。將所得懸浮液在氬氣氛圍下回流20小時(shí)。反應(yīng)完成后，通過Celite墊（Celite 577 fine）過濾，濾液經(jīng)減壓濃縮得到粗產(chǎn)物。粗產(chǎn)物通過快速柱色譜法純化，洗脫劑為二氯甲烷/甲醇/三乙胺（3:1:0.1，v/v/v），得到1.31 g目標(biāo)化合物3-Boc-氨甲基哌啶，為無色粘性油狀物。產(chǎn)率：91%；薄層色譜Rf = 0.33（二氯甲烷/甲醇/三乙胺 = 3:1:0.1）；1H NMR (400 MHz, CDCl3) δ: 1.08 (qd, J = 11.2, 4.0 Hz, 1H, CH2CHAHBCH), 1.42 (s, 9H, 3×CH3), 1.45-1.52 (m, 1H, CHAHBCH2CH), 1.58-1.70 (m, 2H, CHAHBCHAHBCH), 1.76-1.82 (m, 1H, CH), 2.32 (t, J = 11.2 Hz, 1H, NHCHAHBCH), 2.52-2.60 (m, 2H, CH2CHAHBNH), 2.97-3.03 (m, 3H, CH2NHCO + CH2CHAHBNH), 3.06 (dd, J = 11.6, 3.2 Hz, 1H, NHCHAHBCH), 4.63 (br s, 1H, NHCO); 13C NMR (100 MHz, CDCl3) δ: 24.99, 27.97, 28.27, 36.86, 43.74, 45.90, 49.54, 78.28, 155.86; ESI-HRMS m/z 計(jì)算值 C11H23N2O2 [M+H]+ 215.1760，實(shí)測值 215.1763; IR (KBr) υ: 3385, 2978, 2934, 1685, 1528, 1458, 1367, 1272, 1254, 1174, 1009 cm-1。
參考文獻(xiàn)：
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4442 - 4452
[2] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 2, p. 633 - 645
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 1, p. 119 - 139
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2025/05/22 | 43751 | 3-Boc-氨基哌啶 3-(BOC-Amino)piperidine, 97%, Thermo Scientific Chemicals | 142643-29-6 | 1g | 622元 |
| 2025/05/22 | 43751 | 3-Boc-氨基哌啶 3-(BOC-Amino)piperidine, 97%, Thermo Scientific Chemicals | 142643-29-6 | 5g | 2259元 |
| 2025/05/22 | XW1726030532 | 3-(BOC-氨基)哌啶 3-(tert-butoxycarbonylamino)piperidine;3-tert-butoxycarbonylaminopiperidine;3-(boc-amino)piperidine;tert-butyl piperidin-3-ylcarbamate | 142643-29-6 | 5G | 64元 |