1450-72-2
1450-72-2 結(jié)構(gòu)式
基本信息
2'-羥基-5'-甲基苯乙酮
1-(2-HYDROXY-5-METHYLPHENYL)ETHAN-1-ONE
1-(2-HYDROXY-5-METHYLPHENYL)ETHANONE
2-ACETYL-4-METHYLPHENOL
2'-HYDROXY-5'-METHYLACETOPHENONE
2-HYDROXY-5-METHYLACETOPHENONE
ASISCHEM D38759
AURORA 16683
OTAVA-BB BB7013941401
TIMTEC-BB SBB005399
1-(2-hydroxy-5-methylphenyl)-ethanon
1-Hydroxy-2-acetyl-4-methylbenzene
2’-Hydroxy-5’-methylacetophenon
5’-Methyl-2’-hydroxyacetophenone
Acetophenone, 2'-hydroxy-5'-methyl-
Acetophenone,2’-hydroxy-5’-methyl-
Ethanone,1-(2-hydroxy-5-methylphenyl)-
o-Acetyl-p-cresol
2-Hydroxy-5-methylacetophenone ,98%
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
140-39-6
1450-72-2
以乙酸對(duì)甲酚酯為原料合成2-羥基-5-甲基苯乙酮的一般步驟如下：在500毫升圓底燒瓶中加入對(duì)甲苯基乙酸酯（10克，0.067摩爾）和氯化鋁（10.7克，0.08摩爾）。將反應(yīng)混合物置于140-150℃的油浴中加熱5-6小時(shí)。反應(yīng)進(jìn)程通過(guò)薄層色譜（TLC）監(jiān)測(cè)，使用乙酸乙酯：己烷作為展開(kāi)劑。反應(yīng)完成后，用碎冰淬滅反應(yīng)混合物，所得固體產(chǎn)物用乙酸乙酯（2×50毫升）萃取。有機(jī)相用鹽水溶液（2×15毫升）洗滌，并用無(wú)水硫酸鈉干燥。隨后，通過(guò)減壓蒸餾去除溶劑，得到粗產(chǎn)物。粗產(chǎn)物通過(guò)水溶液乙醇重結(jié)晶純化，得到目標(biāo)化合物2-羥基-5-甲基苯乙酮，產(chǎn)率為92%，熔點(diǎn)為45-48°C。
參考文獻(xiàn)：
[1] Journal of Organic Chemistry, 1981, vol. 46, p. 4971 - 4975
[2] Journal of Chemical Research, Miniprint, 2003, # 12, p. 1258 - 1270
[3] Journal of Chemical Research, Synopses, 1999, # 9, p. 574 - 575
[4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996, vol. 35, # 7, p. 734 - 736
[5] Journal of Chemical Research, Miniprint, 1998, # 10, p. 2678 - 2695
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | A13136 | 2'-羥基-5'-甲基苯乙酮, 98% 2'-Hydroxy-5'-methylacetophenone, 98% | 1450-72-2 | 5g | 302元 |
| 2025/05/22 | A13136 | 2'-羥基-5'-甲基苯乙酮, 98% 2'-Hydroxy-5'-methylacetophenone, 98% | 1450-72-2 | 25g | 1233元 |
| 2025/05/22 | 012138 | 氮化鋯, 99.5% (metals basis 去除鉿), Hf <3% Zirconium nitride, 99.5% (metals basis excluding Hf), Hf <3%, Thermo Scientific Chemicals | 1450-72-2 | 25g | 680元 |