2491-18-1
2491-18-1 結(jié)構(gòu)式
基本信息
L-蛋氨酸甲脂鹽酸鹽
蛋氨酸甲酯鹽酸鹽
L-蛋氨酸甲酯鹽酸鹽
L-甲硫氨酸甲酯鹽酸鹽
L-環(huán)丙氨酸甲酯
L-甲硫氨酸甲酯鹽酸鹽/L-蛋氨酸甲酯鹽酸鹽
H-MET-OME HYDROCHLORIDE
L-METHIONINE METHYL ESTER HYDROCHLORIDE
L-METHIONINE METHYL ESTER HYDROCHLORIDE SALT
METHIONINE-OME HCL
methyl L-methionate hydrochloride
L-Methionine Methyl Ester HCl
H-MET-OME.HCLL-METHIONINE METHYL ESTER HYDROCHLORIDE
H-Met-OMeCl
L-Methioninemethylesterhydrochloride,99%
H-Met-OMe•
H-L-Met-OMe*HCl
(2S)-2-Amino-4-methylsulfanylbutanoate hydrochloride
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
67-56-1
63-68-3
2491-18-1
合成實(shí)施例1：將L-蛋氨酸（0.5 g，1當(dāng)量）懸浮于裝有磁力攪拌子的100 mL圓底燒瓶中，加入甲醇（30 mL，濃度為0.1 M），并在氮?dú)夥諊吕鋮s至0℃。緩慢滴加亞硫酰氯（0.5 mL，2當(dāng)量）至上述懸浮液中，隨后加熱回流反應(yīng)16小時(shí)。反應(yīng)完成后，通過旋轉(zhuǎn)蒸發(fā)儀除去溶劑，得到淺黃色固體。將該固體用熱乙醚研磨，過濾去除乙醚溶液，得到白色固體L-蛋氨酸甲酯鹽酸鹽（0.65561 g，收率98%）。產(chǎn)物經(jīng)真空干燥進(jìn)一步純化。1H NMR (D2O, 500 MHz) δH: 4.24 (1H, m, CH), 3.79 (3H, s, OCH3), 2.63 (2H, t, CH2), 2.25 (1H, m, CH2), 2.16 (1H, m, CH2), 2.06 (1H, s, SCH3). 13C NMR (D2O, 125 MHz) δC: 170.58 (C=O), 53.64 (OCH3), 51.70 (CH), 28.71 (CH2), 28.41 (CH2), 13.85 (SCH3). IR (neat, vmax, cm-1): 2880.8/2676.2 (CH3, CH2, CH), 2016.2, 1742.2 (C=O, ester), 1483.6, 1443.5, 1227, 1194.7, 1149.8, 1079.5 (C-O). HRMS m/z (+ESI): C6H14NO2S, calculated mass = 164.074 (error = 0.07 ppm).
參考文獻(xiàn)：
[1] Journal of Organic Chemistry, 2011, vol. 76, # 1, p. 201 - 215
[2] Journal of the American Chemical Society, 2017, vol. 139, # 40, p. 14077 - 14089
[3] Patent: WO2012/131313, 2012, A1. Location in patent: Page/Page column 49
[4] Patent: US2014/39200, 2014, A1. Location in patent: Paragraph 0376-0380
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 8, p. 1942 - 1944
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2025/05/22 | A15952 | L-蛋氨酸甲酯鹽酸鹽, 99% L-Methionine methyl ester hydrochloride, 99% | 2491-18-1 | 5g | 306元 |
| 2025/05/22 | A15952 | L-蛋氨酸甲酯鹽酸鹽, 99% L-Methionine methyl ester hydrochloride, 99% | 2491-18-1 | 25g | 594元 |
| 2025/05/22 | A15952 | L-蛋氨酸甲酯鹽酸鹽, 99% L-Methionine methyl ester hydrochloride, 99% | 2491-18-1 | 100g | 2380元 |