27387-31-1
27387-31-1 結(jié)構(gòu)式
基本信息
9-甲基-1,2,3,4-四氫咔唑酮
1,2,3,9-四氫-9-甲基-4H-咔唑酮
N-甲基四氫咔唑酮
1,2,3,4-四氫-9-甲基咔唑-4-酮
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
1,2,3,9-TETRAHYDRO-4-OXO-CARBAZOLE
1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONE
1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOLE-4-ONE
1,2,3,9-TETRAHYDRO-9-METHYL CARBAZOLE-4-ONE
9-METHYL-1,2,3,4-TETRAHYDRO-4-OXOCARBAZOLE
9-METHYL-1,2.3,4-TETRAHYDRO-4-OXOCARBAZOLE-4-ONE
9-METHYL-1,2,3,9-TETRAHYDRO-4H-CARBAZOL-4-ONE
9-METHYL-1,2,3,9-TETRAHYDRO-CARBAZOL-4-ONE
9-METHYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-4-ONE
1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One99%
N-Methylcarbazolone
1,2,3,9-Tetrahydro-9-Methyl-4H
1,2,3,4-TETRAHYDRO-9-METHCARBAZOL-4-ONE
1,2,3,9-Tetrahydro-4H-9-methyl-carbazole-4-one
N-METHYL-4-OXO-1,2,3,4-TETRAHYDROCARBAZOLE
1,2,3,4-tetrahydro-4-oxocarbazolt
1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONEONDANSETRON
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
15128-52-6
4637-24-5
27387-31-1
以2,3-二氫-1H-咔唑-4(9H)-酮（1.0 mmol）和N,N-二甲基甲酰胺二甲基縮醛（10 mmol）為原料，在N,N-二甲基甲酰胺（5.0 mL）中回流反應(yīng)1.0小時(shí)。反應(yīng)完成后，將混合物冷卻至室溫，用乙酸乙酯（2×25 mL）萃取。分離有機(jī)層，用飽和鹽水溶液洗滌，隨后用無(wú)水Na2SO4干燥。減壓濃縮除去溶劑，所得固體用乙醇重結(jié)晶，得到白色針狀晶體，收率71%，熔點(diǎn)188-190℃。IR（cm-1）: 1695（C=O）。1H NMR（400 MHz, CDCl3）δ: 2.24-2.27（t, 2H, CH2, J = 6.28 Hz）, 2.56-2.59（t, 2H, CH2, J = 6.0 Hz）, 2.91-2.94（t, 2H, CH2, J = 6.21 Hz）, 3.70（s, 3H, NCH3）, 7.27-7.30（m, 3H, Ph）, 8.24-8.26（m, 1H, Ph）。元素分析計(jì)算值（C13H13NO）: C, 78.36; H, 6.58; N, 7.03%。實(shí)測(cè)值: C, 78.29; H, 6.49; N, 6.92%。
參考文獻(xiàn)：
[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014, vol. 53B, # 12, p. 1606 - 1610
[2] Journal of Molecular Structure, 2014, vol. 1080, p. 137 - 144
[3] Russian Chemical Bulletin, 2005, vol. 54, # 8, p. 1887 - 1891
常見(jiàn)問(wèn)題列表
1,2,3,4-四氫-9-甲基-4H-咔唑酮（昂丹司瓊EP雜質(zhì)C）用于制備5-HT3調(diào)節(jié)劑，治療和預(yù)防介導(dǎo)疾病。本品是昂丹司瓊的雜質(zhì)。
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/05/22 | T2942 | 1,2,3,4-四氫-9-甲基咔唑-4-酮 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one | 27387-31-1 | 5g | 80元 |
| 2025/05/22 | T2942 | 1,2,3,4-四氫-9-甲基咔唑-4-酮 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one | 27387-31-1 | 25g | 310元 |
| 2025/05/22 | XW022738731104 | 1,2,3,4-四氫-9-甲基-4H-咔唑酮 | 27387-31-1 | 100G | 455元 |