5454-82-0

基本信息
1-環(huán)丁基甲胺鹽酸鹽
(環(huán)丁基甲基)胺鹽酸鹽
(氨基甲基)環(huán)丁烷鹽酸鹽
CyclobutylMethylaMine, HCl
CyclobutaneMethanaMine HCl
(aMinoMethyl)cyclobutane hcl
Cyclobutylmethylamine hydrochloride
CyclobutaneMethanaMine hydrochloride
1-CyclobutylMethylaMine hydrochloride
(AMinoMethyl)cyclobutane hydrochloride
CyclobutaneMethanaMine, hydrochloride (1:1)
物理化學性質
制備方法

4426-11-3

5454-82-0
以環(huán)丁烷甲腈為原料合成環(huán)丁基甲胺鹽酸鹽的一般步驟:在氬氣保護下,將硼烷的四氫呋喃溶液(1M,296mL,296mmol)緩慢加入至環(huán)丁烷甲腈(20g,247mmol)的四氫呋喃(60mL)溶液中。將反應混合物加熱至回流,并保持過夜。反應完成后,將混合物置于冰水浴中冷卻,緩慢滴加甲醇(120mL),控制反應溫度低于20℃。隨后,加入4M鹽酸的甲醇溶液(300mL),繼續(xù)控制溫度低于20℃。將所得溶液加熱回流2.5小時。反應結束后,冷卻并濃縮混合物。殘余物用甲醇(100mL)稀釋后再次濃縮,重復此過程。向殘余物中加入乙醚,攪拌30分鐘后過濾,得到標題化合物環(huán)丁基甲胺鹽酸鹽(25.9g,收率86%),為白色固體。核磁共振氫譜(300MHz,DMSO-d6)δ ppm:1.70-1.86(m,4H),1.97-2.04(m,2H),2.46-2.61(m,1H),2.75-2.84(m,2H),8.02(br s,3H)。
參考文獻:
[1] Patent: WO2015/25164, 2015, A1. Location in patent: Paragraph 59
[2] Patent: US2015/57298, 2015, A1. Location in patent: Page/Page column 19
[3] Patent: WO2011/97491, 2011, A1. Location in patent: Page/Page column 71-72
[4] Patent: WO2005/75464, 2005, A1. Location in patent: Page/Page column 22
[5] Patent: WO2005/74939, 2005, A1. Location in patent: Page/Page column 59