55745-70-5

基本信息
2,3-二氫苯并呋喃-5-甲醛
2,3-二氫-5-醛基-1-苯并呋喃
2,3-二氫苯并[B]呋喃-5-甲醛
2,3-二氫本并呋喃-5-甲醛
2,3-DIHYDRO-1-BENZOFURAN-5-CARBALDEHYDE
2,3-DIHYDROBENZO[B]FURAN-5-CARBALDEHYDE
2,3-DIHYDROBENZO[B]FURAN-5-CARBOXALDEHYDE
2,3-DIHYDROBENZOFURAN-5-CARBALDEHYDE
2,3-DIHYDROBENZOFURAN-5-CARBOXALDEHYDE
AKOS MSC-0772
BUTTPARK 27\04-60
TIMTEC-BB SBB005559
2,3-dihyro-1-benzofuran-5-carbaldehyde
5-Benzofurancarboxaldehyde, 2,3-dihydro- (6CI,9CI)
2,3-Dihydro-5-benzofurancarbox
2,3-dihyro-1-benzofuran-5-carb
2,3-Dihydrobenzo[b]furan-5-carbaldehyde, 95+%
2,3-Dihydro-5-benzofurancarbaldehyde
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表

496-16-2

68-12-2

55745-70-5
2,3-二氫苯并呋喃-5-甲醛的合成步驟如下:在干燥的反應(yīng)瓶中,將2,3-二氫苯并呋喃(100g,0.833mol)溶解于N,N-二甲基甲酰胺(355.0ml)中。在攪拌下,緩慢滴加氯氧化磷(255.58g,1.666mol),控制反應(yīng)溫度維持在80℃至85℃之間。反應(yīng)混合物在此溫度下持續(xù)攪拌4至5小時,期間通過高效液相色譜(HPLC)監(jiān)測反應(yīng)進(jìn)度。反應(yīng)完成后,將混合物小心倒入冰水中淬滅反應(yīng)。隨后,用甲苯(2000ml)進(jìn)行萃取,分離有機(jī)層。有機(jī)層依次用5%碳酸氫鈉溶液(500ml)和10%鹽水溶液(500ml)洗滌以去除殘余的酸和DMF。洗滌后的有機(jī)層在50℃至60℃下進(jìn)行減壓蒸餾,除去溶劑,得到粗產(chǎn)物。通過進(jìn)一步純化,得到2,3-二氫苯并呋喃-5-甲醛,產(chǎn)率為85%至90%,純度為90%至92%。
參考文獻(xiàn):
[1] Patent: EP1792899, 2007, A1. Location in patent: Page/Page column 11
[2] Patent: WO2010/41271, 2010, A2. Location in patent: Page/Page column 28
[3] Letters in Drug Design and Discovery, 2013, vol. 10, # 7, p. 561 - 571
[4] Patent: CN102766135, 2017, B. Location in patent: Paragraph 0035-0036
[5] Journal of Medicinal Chemistry, 2002, vol. 45, # 19, p. 4222 - 4239
知名試劑公司產(chǎn)品信息
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2025/05/22 | H59602 | 2,3-二氫苯并[b]呋喃-5-甲醛, 97% 2,3-Dihydrobenzo[b]furan-5-carboxaldehyde, 97% | 55745-70-5 | 1g | 358元 |
2025/05/22 | H59602 | 2,3-二氫苯并[b]呋喃-5-甲醛, 97% 2,3-Dihydrobenzo[b]furan-5-carboxaldehyde, 97% | 55745-70-5 | 5g | 1171元 |
2025/05/22 | D3857 | 2,3-二氫苯并呋喃-5-甲醛 2,3-Dihydrobenzofuran-5-carboxaldehyde | 55745-70-5 | 5G | 280元 |