584-85-0
584-85-0 結構式
基本信息
L-安酸呤
BETA-丙氨?；?3-甲基-L-組氨酸
(S)-2-(3-氨基丙酰胺基)-3-(1-甲基-1H-咪唑-5-基)丙酸
L-Anserine
H-β-Ala-His(3-Me)-OH
L-Histidine, β-alanyl-3-methyl-
beta-Alanyl-3-methyl-L-histidine
L-N-beta-Alanyl-3-methylhistidine
N-beta-alanyl-3-methyl-L-histidine
Nα-β-Alanyl-1-dehydro-3-methyl-L-histidine
2-(3-aminopropanoylamino)-3-(3-methylimidazol-4-yl)-propanoic acid
(S)-2-(4-Aminobutanamido)-3-(1-methyl-1H-imidazol-5-yl)propanoic acid
物理化學性質
常見問題列表
![L-Histidine, N-[3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]-3-methyl-, methyl ester](/CAS/20210305/GIF/952739-81-0.gif)
952739-81-0
584-85-0
以化合物（CAS: 952739-81-0）為起始原料，合成(S)-2-(3-氨基丙酰胺基)-3-(1-甲基-1H-咪唑-5-基)丙酸的一般步驟如下：向含有酯14（18.8 mg，53.0 μmol）的甲醇（1 mL）溶液中，加入1 M氫氧化鈉水溶液調節(jié)pH至>11。將反應混合物在室溫下攪拌反應16小時。反應完成后，通過蒸發(fā)去除溶劑，得到膠狀殘余物。將該殘余物溶解于蒸餾水（1 mL）中，隨后用1 M鹽酸水溶液酸化反應混合物。
參考文獻：
[1] Synlett, 2016, vol. 27, # 19, p. 2734 - 2736
[2] Synthesis, 2007, # 17, p. 2608 - 2610
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Human Endogenous Metabolite
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Anserine (drinking water at a concentration of 2.0?g/L (equivalent to 10?mg/mouse); for 8 weeks) completely recoveres the memory deficits, improves pericyte coverage on endothelial cells in the brain, and diminishes chronic glial neuroinflammatory reactions in AβPPswe/PSEN1dE9 Alzheimer's disease (AD) model mice over 18-months old.