6099-03-2
6099-03-2 結(jié)構(gòu)式
基本信息
2-甲氧基肉桂酸
鄰甲氧基肉桂酸
間甲氧基肉桂酸
2-甲氧基肉桂酸, 98+%
3-(2-METHOXYPHENYL)ACRYLIC ACID
AKOS BBB/196
AKOS BBS-00007900
AURORA 11318
METHOXYCINNAMIC ACID,2-
O-METHOXYCINNAMIC ACID
RARECHEM BK HC T255
TRANS-2-METHOXYCINNAMIC ACID
TRANS-3-(2-METHOXYPHENYL)ACRYLIC ACID
TRANS-O-METHYL-O-COUMARIC ACID
TRANS-O-METHYL-O-CUMARIC ACID
Cinnamic acid, o-methoxy-
(2E)-3-(2-methoxyphenyl)prop-2-enoic acid
2-Methoxycinnamic acid,predominantly trans
2-METHOXYCINNAMIC ACID, 98%, PREDOMINANTLY TRANS
2-Methoxycinnamic acid, 98+%
2-Propenoic acid, 3-(2-methoxyphenyl)-
3-(2-Methoxyphenyl)prop-2-enoic acid, 3-(2-Hydroxyphenyl)acrylic acid
(2E)-3-(2-methoxyphenyl)acrylic acid
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
141-82-2
135-02-4
6099-03-2
向500 mL三頸圓底燒瓶中加入鄰甲氧基苯甲醛（20 g，146.90 mmol，1.00當(dāng)量）、吡啶（250 mL）、丙二酸（18.3 g，175.86 mmol，1.20當(dāng)量）和哌啶（2.5 g，29.36 mmol，0.20當(dāng)量）。將反應(yīng)混合物在85°C下攪拌過(guò)夜。反應(yīng)完成后，減壓蒸餾除去大部分溶劑，隨后用鹽酸水溶液將剩余溶液的pH值調(diào)節(jié)至3.0。通過(guò)過(guò)濾收集析出的固體，得到25.6 g（產(chǎn)率98%）2-甲氧基肉桂酸，為白色固體。
參考文獻(xiàn)：
[1] Patent: WO2014/182950, 2014, A1. Location in patent: Paragraph 00322; 00323
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 336 - 343
[3] Journal of the Indian Chemical Society, 1988, vol. 65, # 3, p. 187 - 191
[4] Molecules, 2009, vol. 14, # 10, p. 4166 - 4179
[5] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 15, p. 4513 - 4519