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Fluzoparib

Fluzoparib Struktur
1358715-18-0
CAS-Nr.
1358715-18-0
Englisch Name:
Fluzoparib
Synonyma:
HS10160;Fuzuopali;Fluzoparib;Fuzuloparib;Fluzoparib, 10 mM in DMSO;Sulfamethoxazole Impurity 21;1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]-;SHR 3162,homologous recombination repair,Inhibitor,poly ADP ribose polymerase,Fluzoparib,inhibit,ovarian,PARP,PARP1,SHR-3162,Fuzuloparib,cancer
CBNumber:
CB08093053
Summenformel:
C22H16F4N6O2
Molgewicht:
472.4
MOL-Datei:
1358715-18-0.mol

Fluzoparib Eigenschaften

Dichte
1.59±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO : 50 mg/mL (105.84 mM; Need ultrasonic)
Aggregatzustand
Solid
pka
12.06±0.40(Predicted)
Farbe
White to off-white

Sicherheit

Fluzoparib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Fuzuloparib is mainly used to treat patients with recurrent ovarian, fallopian tube or primary peritoneal cancer that is sensitive to platinum-based drugs, especially those with germline breast cancer oncogene (BRCA) mutations. Tumor cells with BRCA mutations are particularly sensitive to PARP inhibitors due to defects in the homologous recombination (HR) repair pathway.

Mechanism of action

Fuzuloparib is an orally active poly(ADP-ribose) polymerase (PARP) inhibitor. PARP plays an important role in the cell's DNA damage response (DDR) and promotes the recruitment of DNA repair mechanisms by catalyzing PARylation. Fuzuloparib inhibits the function of PARP, leading to the accumulation of DNA double-strand breaks (DSBs) in tumor cells, ultimately achieving synthetic lethality.

Synthese

The synthesis started with 2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrazole, which was first reduced to the tetrahydropyrazole and then converted to the hydrochloride salt 26.2. Fuzuloparib (26) was prepared by HATU-mediated amidation of 26.2 with benzoic acid 26.3 in 88% yield.
Fluzoparib

Fluzoparib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Fluzoparib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 43)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196
sale04@alfachem.cn China 12188 58
TargetMol Chemicals Inc.
+17819995354
marketing@targetmol.com United States 32284 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38668 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8467 58
Aladdin Scientific

tp@aladdinsci.com United States 57505 58
Shanghai Hanhong Scientific Co., Ltd.
+undefined17612118332
Lucky@hanhonggroup.com China 6035 58
Chengdu Peter-like Biotechnology Co., Ltd. 18108052721 18108052721
2850505130@qq.com China 5173 58
Taizhou Nanfeng Pharmaceutical Research Institute nanfengdrug@163.com; 18616377689
nanfengdrug@163.com China 20010 58

  • 1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]-
  • Fuzuopali
  • Fuzuloparib
  • HS10160
  • Fluzoparib
  • SHR 3162,homologous recombination repair,Inhibitor,poly ADP ribose polymerase,Fluzoparib,inhibit,ovarian,PARP,PARP1,SHR-3162,Fuzuloparib,cancer
  • Sulfamethoxazole Impurity 21
  • Fluzoparib, 10 mM in DMSO
  • 1358715-18-0
  • C22H16F4N6O2
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