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Nimodipin

Nimodipine Struktur
66085-59-4
CAS-Nr.
66085-59-4
Bezeichnung:
Nimodipin
Englisch Name:
Nimodipine
Synonyma:
NIMOTOP;2-methyo-xyethyl 1-methylethyl ester;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) ester;Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester;ADMON;PERIPLUM;Nimodipin;Nimodipime;NIMODIPINE;BAY E 9736
CBNumber:
CB1398087
Summenformel:
C21H26N2O7
Molgewicht:
418.44
MOL-Datei:
66085-59-4.mol

Nimodipin Eigenschaften

Schmelzpunkt:
125°C
Siedepunkt:
536.21°C (rough estimate)
Dichte
1.3268 (rough estimate)
Brechungsindex
1.6500 (estimate)
storage temp. 
2-8°C
L?slichkeit
methanol: 62.5 mg/mL
Aggregatzustand
solid
pka
2.77±0.70(Predicted)
Farbe
white
Merck 
14,6551
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI
InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
InChIKey
UIAGMCDKSXEBJQ-UHFFFAOYSA-N
SMILES
C1(C)NC(C)=C(C(OC(C)C)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OCCOC)=O
CAS Datenbank
66085-59-4(CAS DataBase Reference)
NIST chemische Informationen
Nimodipine(66085-59-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/21/22-48/22
S-S?tze: 36
WGK Germany  1
RTECS-Nr. US7975500
HazardClass  IRRITANT
HS Code  29333990
Toxizit?t LD50 in mice, rats (mg/kg): 3562, 6599 orally; 33, 16 i.v. (Schlüter)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Nimodipin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Nimodipine is a cerebral vasodilating calcium antagonist related to nifedipine. It is indicated for the prophylaxis and treatment of neurological deficits due to cerebral vasospasm after subarachnoid hemorrhage.

Chemische Eigenschaften

Crystalline Solid

Verwenden

Nimodipine has been used:
  • as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections
  • as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC)
  • in the pharmacological studies for the measurement of spine voltage escape

Definition

ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.

Allgemeine Beschreibung

Nimodipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)- 3,5-pyridinedicarboxylic acid 2-methoxyethyl1-methylethyl ester (Nimotop), is another dihydropyridinecalcium channel blocker but differs in that it dilatesthe cerebral blood vessels more effectively than do the otherdihydropyridine derivatives. This drug is indicated for treatmentof subarachnoid hemorrhage-associated neurologicaldeficits.

Biologische Aktivit?t

L-type Ca 2+ channel blocker.

Nimodipin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Isopropylacetoacetat (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER Ethanol 2-Methoxy-ethanol 3-Nitrobenzaldehyd Crotons?ure 2-Methoxyethylacetoacetat Ammoniak, wssrige Lsung

Downstream Produkte

NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS)

Nimodipin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 468)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Changzhou Rokechem Technology Co., Ltd. 		18758118018
 sales001@rokechem.com China 255 58
airuikechemical co., ltd. 		+86-18353166132
sales02@airuikechemical.com China 983 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD 		+86-15350851019; +8615350851019
 admin@86-ss.com China 1000 58
Shandong Xuhuang New material CoLTD 		+86-15095020839 +86-17660422208
 China 726 58
Capot Chemical Co.,Ltd. 		+8613336195806
 sales@capot.com China 29733 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21622 55
Shanghai Zheyan Biotech Co., Ltd. 		18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29855 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338
 stella@zetchem.com China 2136 58

66085-59-4(Nimodipin)Verwandte Suche:

  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) ester
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-(1-methylethyl) ester
  • Nimodipine,1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridine
  • Nimodipime
  • Isopropyl 2-methoxyethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Nimodipine (125 mg)
  • NiModipine(NiMotop)
  • 1,4-Dihydro-2,6-diMethyl-4-(3-nitrophenyl)-
  • Isopropyl 2-Methoxyethyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
  • 3-isopropyl 5-(2-Methoxyethyl) 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid- 3-(2-methoxyethyl) 5-(1-methylethyl) ester
  • 1-methylethyl 2-(methyloxy)ethyl 2,6-dimethyl-4-(3-nitroph
  • 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-isopropyl O5-(2-methoxyethyl) ester
  • Nimodipine (USAN/INN)
  • O3-isopropyl O5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Nimodipine, >=99%
  • NIMODIPINE CALCIUM CHANNEL ANTAG
  • NIMODIPINE ASSAY STANDARD BP(CRM STANDARD)
  • NIMODIPINE BP STANDARD(CRM STANDARD)
  • NIMODIPINE EPN(CRM STANDARD)
  • NIMODIPINE MM(CRM STANDARD)
  • inedicarboxylate
  • isopropyl2-methoxyethyl1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyrid
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester
  • O5-(2-Methoxyethyl) O3-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5 pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester
  • NIMODIPINE
  • PERIPLUM
  • ADMON
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(3'-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHOXYETHYL-1-METHYLETHYL ESTER
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHOXYETHYL 1-METHYLETHYL ESTER
  • 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHYLOXYETHYL 1-METHYLETHYL ESTER
  • isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
  • BAY E 9736
  • Bay e 9736, Admon, Nimotop, periplum
  • NIMODIPINE(PATENT-NOSUPPLY)
  • Nimodipin
  • 2，6-Dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester
  • 1,4-Dihydro-2,6-dimethyl-4-(3-ni-trophenyl)-3,5-pyridinedicarboxylicacid
  • ethoxyethyl1-methylethylester
  • Isopropyl 2-methoxyethyl
  • Nimodipine - CAS 66085-59-4 - Calbiochem
  • nimodipine api
  • Nimodipine BP
  • (4R)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid O3-(2-methoxyethyl) ester O5-propan-2-yl ester
  • Nimodipine, 99%, an analogue of the calcium channel blocker nifedipine
  • Nimodipine>
  • Nimodipine CRS
  • Nimodipine for peak identification
  • (R)-3-isopropyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Nimodipine USP/EP/BP
  • NIMODIPINE (BAY-e 9736)
  • NimodipineQ: What is Nimodipine Q: What is the CAS Number of Nimodipine Q: What is the storage condition of Nimodipine Q: What are the applications of Nimodipine
  • Nimodipine (1463858)
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) ester
  • NIMOTOP
  • 2-methyo-xyethyl 1-methylethyl ester
  • Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester
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