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Esaxerenone

Esaxerenone Struktur
1632006-28-0
CAS-Nr.
1632006-28-0
Englisch Name:
Esaxerenone
Synonyma:
cs3150;cs-3150;CS-2614;XL-550);Esaxerenone;5G,100G,500G;Esaxerenone(CS-3150);CS-3150 (Esaxerenone;Esaxerenone, 10 mM in DMSO;CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.
CBNumber:
CB33159937
Summenformel:
C22H21F3N2O4S
Molgewicht:
466.48
MOL-Datei:
1632006-28-0.mol

Esaxerenone Eigenschaften

Siedepunkt:
581.3±50.0 °C(Predicted)
Dichte
1.35±0.1 g/cm3(Predicted)
L?slichkeit
DMSO:100.0(Max Conc. mg/mL);214.37(Max Conc. mM)
pka
12.76±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to light yellow
InChI
InChI=1S/C22H21F3N2O4S/c1-14-18(21(29)26-15-7-9-16(10-8-15)32(2,30)31)13-27(11-12-28)20(14)17-5-3-4-6-19(17)22(23,24)25/h3-10,13,28H,11-12H2,1-2H3,(H,26,29)
InChIKey
NOSNHVJANRODGR-UHFFFAOYSA-N
SMILES
C(N1C=C(C(=O)NC2C=CC(S(=O)(=O)C)=CC=2)C(C)=C1C1C=CC=CC=1C(F)(F)F)CO

Sicherheit

Esaxerenone Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Esaxerenone, is a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.

Biologische Aktivit?t

Esaxerenone exerts its antihypertensive effect by blocking excessive activation of the mineralocorticoid receptor by endogenous ligands (such as aldosterone), has a mineralocorticoid receptor selectivity at least 1000-fold greater than other steroid hormone receptors, a long half-life, high oral bioavailability, and has a more significant antihypertensive effect than spironolactone or eplerenone.

Synthese

below shows the synthesis route of Esaxerenone
Esaxerenone synthesis route

Esaxerenone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Esaxerenone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 69)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354
 marketing@targetmol.com United States 32376 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Shanghai Innopharm Industrial Co., Ltd. 		+86-21-59960785 +86-17701845089
 sales@hoyaopharm.com China 338 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
Aladdin Scientific
tp@aladdinsci.com United States 52924 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323658 +86-18168183658
 sales1@artkmedchem.com China 39002 58
Shanghai Famo Biotech Co Ltd 		+86-36680037 +86-18550473860
 mayan@famobiotech.com;sales@famobiotech.com China 528 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
Shaanxi Dideu New Materials Co. Ltd 		+86-18192503167
1036@dideu.com China 6395 58
  • cs3150
  • cs-3150
  • Esaxerenone
  • CS-3150 (Esaxerenone
  • XL-550)
  • CS-2614
  • 5G,100G,500G
  • CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.
  • 1H-Pyrrole-3-carboxamide, 1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-, (5S)-
  • 1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide
  • Esaxerenone(CS-3150)
  • Esaxerenone,Inhibitor,Mineralocorticoid Receptor,CS 3150,CS3150,inhibit,XL550,XL 550
  • 1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide
  • Esaxerenone, 10 mM in DMSO
  • 1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide , Esaxerenone
  • (5P)-1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2- (trifluoromethyl) phenyl]-1H-pyrrole-3-carboxamide
  • 1632006-28-0
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