POMALIDOMIDE-PEG2-CO2H Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block Pomalidomide-PEG₂-CO₂H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

POMALIDOMIDE-PEG2-CO2H Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

POMALIDOMIDE-PEG2-CO2H Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	32282	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8647	58
Zhengzhou Lingzhiyue Technology Co., Ltd	+86-0371-55074660 +86-13783527580	Lingzhiyue@aliyun.com	China	3145	58
Nanjing Bicbiotechnology Co., Ltd	+86-2552131256 +86-18251840740	sales@bicbiotech.com	China	5994	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068 +86-15680926068	1924344760@confluore.cn	China	2996	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	6585	65
ChemShuttle, Inc.	0150-83588313-811 18800520310	sales@chemshuttle.com	China	2999	62
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	25003	65
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80

---

• POMALIDOMIDE-PEG2-CO2H
• Pomalidomide-PEG2-COOH
• Pomalidomide-PEG2-CO2H >=98%
• NUN 07174
• Thalidomide-4-NH-PEG2-COOH
• Thalidomide-NH-PEG2-C2-COOH
• Propanoic acid, 3-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]-
• 3-[2-[2-[[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]ethoxy]propanoic Acid
• Thalidomide-4-NH-PEG2-C2-COOH
• 3-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]propanoic Acid
• Poma-PEG2-COOH
• Pomalidomide-PEG2-Acid
• 3-[2-(2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]propanoic acid
• Pomalidomide 4'-PEG2-acid
• Pomalidomide-PEG₂-CO₂H
• 2140807-17-4
• APIs
• peg