Methyl 3-bromo-5-nitrobenzoate
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- CAS-Nr.
- 6307-87-5
- Englisch Name:
- Methyl 3-bromo-5-nitrobenzoate
- Synonyma:
- DK89898D;Methyl 3-bromo-5-nitrobenzoate;3-Bromo-5-nitro-benzoic acid met;Methyl3-bromo-5-nitrobenzoate98%;Methyl 3-bromo-5-nitrobenzoate 98%;3-Bromo-5-nitro-benzoic acid methyl ester;Benzoic acid, 3-bromo-5-nitro-, methyl ester
- CBNumber:
- CB4957694
- Summenformel:
- C8H6BrNO4
- Molgewicht:
- 260.04
- MOL-Datei:
- 6307-87-5.mol
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Methyl 3-bromo-5-nitrobenzoate Eigenschaften
- Schmelzpunkt:
- 70 °C(Solv: ethanol (64-17-5))
- Siedepunkt:
- 326.0±22.0 °C(Predicted)
- Dichte
- 1.673±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Aggregatzustand
- solid
- Farbe
- Off-white to light brown
- InChI
- InChI=1S/C8H6BrNO4/c1-14-8(11)5-2-6(9)4-7(3-5)10(12)13/h2-4H,1H3
- InChIKey
- DDJCZBFPZLYREP-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC([N+]([O-])=O)=CC(Br)=C1
Methyl 3-bromo-5-nitrobenzoate Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Methyl 3-bromo-5-nitrobenzoate is a pharmaceutical intermediate. Methyl 3-bromo-5-nitrobenzoate can be used to prepare 3-amidobenzoic acid derivatives such as 3-(4-trifluoromethylbenzoyl)amino-5-(2',6'-(2H)piperidinylphenyl)benzoic acid, which have P2Y receptor antagonist effects.
Synthese
The preparation method is achieved through a two-step reaction: first, at 0°C, 3-nitrobenzoic acid is dissolved in concentrated sulfuric acid, N-bromosuccinimide is added, the reaction is carried out at 65°C for 2 hours, and 3-nitro-5-bromobenzoic acid is obtained after stirring with ice water, suction filtration, and drying, with a yield of 95%. Next, the product is dissolved in methanol, SOCl? is added dropwise at 0°C, the reaction is carried out at room temperature for 2 hours, and Methyl 3-bromo-5-nitrobenzoate is finally obtained after treatment with a sodium bicarbonate solution, extraction with ethyl acetate, drying, and column chromatography purification, with a yield of 86.46%.
Methyl 3-bromo-5-nitrobenzoate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Methyl 3-bromo-5-nitrobenzoate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 120)Lieferanten
- Methyl 3-bromo-5-nitrobenzoate
- Methyl 3-bromo-5-nitrobenzoate 98%
- Methyl3-bromo-5-nitrobenzoate98%
- 3-Bromo-5-nitro-benzoic acid methyl ester
- Benzoic acid, 3-bromo-5-nitro-, methyl ester
- DK89898D
- 3-Bromo-5-nitro-benzoic acid met
- 6307-87-5
- 307-87-5
- blocks
- Bromides
- Carboxes
